Abstract
In this letter, a strain sensor with high sensitivity enhancement using a special case of Vernier effect is presented. The sensor configuration is composed of two-fiber loop mirrors in a cascaded configuration with opposite strain responses when individually characterized. Thus, the enhanced Vernier effect is explored, which is the most sensitive of three possible cases Vernier effect. Here, the Vernier response depends on the difference between the sensitivities of each Hi-Bi optical fiber. In addition to this, the fundamental and the first harmonic were also explored. The results obtained are a strain sensitivity of (13.3 +/- 0.3) pm/mu epsilon for the carrier, (80.0 +/- 0.3) pm/mu epsilon or the Vernier envelope of the fundamental case and (120 +/- 1) pm/mu epsilon for the Vernier envelope of the first harmonic. The first harmonic could achieve a magnification factor of 8. Considering that the optical interrogation system allows a minimum resolution of 0.02 nm, the minimum measurement step achievable is 0.2 mu epsilon. This work proves the possibility of applying the concept of enhanced Vernier effect to fiber loop mirrors, obtaining higher sensitivity than a standard fiber loop mirror alone. Besides, the sensitivity can be increased through the usage of harmonics of the Vernier effect. Moreover, the use of large interferometers allows a better discretization of the envelope, which implies a greater ease of analysis.

Abstract
Simple Summary Neoplastic diseases are among the leading causes of death worldwide and constitute the main health problem in both human and veterinary medicine, particularly as the occurrence of the disease continues to increase. Comparative oncology is a quickly expanding field that examines both cancer risk and tumor development across species. Characterized by interdisciplinary collaboration, its goal is the improvement of both human and animal health. Canine neoplastic disease occurs spontaneously and has comparable clinical presentation and pathophysiology to corresponding human cancers. Since the nature of the disease is spontaneous, the complex interactions between tumor cells, tissues and the immune system can be better studied. Such relations are otherwise difficult to study in other experimental animal models. Raman spectroscopy has proved to be a suitable technique to detect and study breast microcalcifications. Raman spectroscopy is a specific and sensitive tool for identifying biomarkers of oncologic disease and also shows further potential in differentiating malignant and benign tumors, and these tumors from healthy tissue. Breast cancer is a health problem that affects individual life quality and the family system. It is the most frequent type of cancer in women, but men are also affected. As an integrative approach, comparative oncology offers an opportunity to learn more about natural cancers in different species. Methods based on Raman spectroscopy have shown significant potential in the study of the human breast through the fingerprinting of biological tissue, which provides valuable information that can be used to identify, characterize and discriminate structures in breast tissue, in both healthy and carcinogenic environments. One of the most important applications of Raman spectroscopy in medical diagnosis is the characterization of microcalcifications, which are highly important diagnostic indicators of breast tissue diseases. Raman spectroscopy has been used to analyze the chemical composition of microcalcifications. These occur in benign and malignant lesions in the human breast, and Raman helps to discriminate microcalcifications as type I and type II according to their composition. This paper demonstrates the recent progress in understanding how this vibrational technique can discriminate through the fingerprint regions of lesions in unstained histology sections from canine mammary glands.

Abstract
The optical Vernier effect consists of overlapping responses of a sensing and a reference interferometer with slightly shifted interferometric frequencies. The beating modulation thus generated presents high magnified sensitivity and resolution compared to the sensing interferometer, if the two interferometers are slightly out of tune with each other. However, the outcome of such a condition is a large beating modulation, immeasurable by conventional detection systems due to practical limitations of the usable spectral range. We propose a method to surpass this limitation by using a few-mode sensing interferometer instead of a single-mode one. The overlap response of the different modes produces a measurable envelope, whilst preserving an extremely high magnification factor, an order of magnification higher than current state-of-the-art performances. Furthermore, we demonstrate the application of that method in the development of a giant sensitivity fibre refractometer with a sensitivity of around 500 mu m/RIU (refractive index unit) and with a magnification factor over 850.

Abstract

Abstract
A fiber sensor composed by a graphene oxide membrane at the tip of a capillary is presented. The graphene oxide membrane acts as a low-reflectivity mirror, distanced from a single mode fiber forming a low finesse Fabry-Perot interferometer. The response of the sensor to acoustic pressure with varying frequency is studied in the range between 5 and 45 kHz, attaining a minimum signal to noise ratio of 14 dB. © 2021 The Author(s).

Abstract
We discuss the novel concept of harmonics of the Vernier effect for optical fiber sensors as a tool to break the limits of conventional optical Vernier effect currently used. The new effect provides enhancements scalable with the harmonic order. © 2021 The Author(s).