Abstract
Deformational Plagiocephaly (DP) refers to an asymmetrical distortion of an infant's skull resulting from external forces applied over time. The diagnosis of this condition is performed using asymmetry indexes that are estimated from specific anatomical landmarks, whose are manually defined on head models acquired using laser scans. However, this manual identification is susceptible to intra-/inter-observer variability, being also time-consuming. Therefore, automatic strategies for the identification of the landmarks and, consequently, extraction of asymmetry indexes, are claimed. A novel pipeline to automatically identify these landmarks on 3D head models and to estimate the relevant cranial asymmetry indexes is proposed. Thus, a template database is created and then aligned with the unlabelled patient through an iterative closest point (ICP) strategy. Here, an initial rigid alignment followed by an affine one are applied to remove global misalignments between each template and the patient. Next, a non-rigid alignment is used to deform the template information to the patient-specific shape. The final position of each landmark is computed as a local weight average of all candidate results. From the identified landmarks, a head's coordinate system is automatically estimated and later used to estimate cranial asymmetry indexes. The proposed framework was evaluated in 15 synthetic infant head's model. Overall, the results demonstrated the accuracy of the identification strategy, with a mean average distance of 2.8 +/- 0.6 mm between the identified landmarks and the ground-truth. Moreover, for the estimation of cranial asymmetry indexes, a performance comparable to the inter-observer variability was achieved.

Abstract
Production scheduling is an optimizing problem that can contribute strongly to the competitive capacity of companies producing goods and services. A way to promote the survival and the sustainability of the organizations in this upcoming era of Industry 4.0 (I4.0) is the efficient use of the resources. A complete failure to stage tasks properly can easily lead to a waste of time and resources, which could result in a low level of productivity and high monetary losses. In view of the above, it is essential to analyse and continuously develop new models of production scheduling. This paper intends to present an I4.0 oriented decision support tool to the dynamic scheduling. After a fist solution has been generated, the developed prototype has the ability to create new solutions as tasks leave the system and new ones arrive, in order to minimize a certain measure of performance. Using a single machine environment, the proposed prototype was validated in an in-depth computational study through several instances of dynamic problems with stochastic characteristics. Moreover, a more robust analysis was done, which demonstrated that there is statistical evidence that the proposed prototype performance is better than single method of scheduling and proved the effectiveness of the prototype.

Abstract
Production scheduling is a function that can contribute strongly to the competitive capacity of companies producing goods and services. Failure to stagger tasks properly causes enormous waste of time and resources, with a clear decrease in productivity and high monetary losses. The efficient use of internal resources in organizations becomes a competitive advantage and can thus dictate their survival and sustainability. In that sense, it becomes crucial to analyze and develop production scheduling models, which can be simplified as the function of affecting tasks to means of production over time. This report is part of a project to develop a dynamic scheduling tool for decision support in a single machine environment. The system created has the ability, after a first solution has been generated, to trigger a new solution as some tasks leave the system and new ones arrive, allowing the user, at each instant of time, to determine new scheduling solutions, in order to minimize a certain measure of performance. The proposed tool was validated in an in-depth computational study with dynamic task releases and stochastic execution time. The results demonstrate the effectiveness of the model.

Abstract
This paper proposes a methodology to detect early signs of Parkinson's disease (PD) through free-speech in uncontrolled background conditions. The early detection mechanism uses signal and speech processing techniques integrated with machine learning algorithms. Three distinct speech databases containing patients' recordings at different stages of the PD are used for estimation of the parameters during the training and evaluation stages. The results reveal the potential in using Random Forest (RF) or Support Vector Machine (SVM) techniques. Once tuned, these algorithms provide a reliable computational method for estimating the presence of PD with a very high accuracy.

Abstract
Goal: The main goal of this research is to analyse the behaviour of a set of ten lot-sizing methods applied to different application scenarios, within the context of more traditional MRP-based manufacturing environments and on JIT/ Kanbans oriented ones. Design/Methodology/Approach: After an extended literature review, a quantitative research method is used to provide a comparative analysis on the performance of the lot-sizing methods under different simulated application scenarios, with variations in demand and peaks of seasonality. Moreover, a final summary provides the error deviations for lot-sizing methods regarding increases in demand variations and seasonality indexes. Results: The study analyses lot-sizing methods and discusses benefits and risks associated to its use in application scenarios marked by a considerable variation in demand or peaks in seasonality. Limitations of the investigation: As the application scenarios did not explore variations in the ordering and stock holding costs, further analysis including these kinds of variations is encouraged. Practical implications: The findings of this research enable the enhancement of the conscience of industrial practitioners, regarding the selection of best suited lot-sizing methods for being applied on each kind of manufacturing scenario, regarding MRP or JIT/Kanban environments. Originality/Value: Given the diversity of the existing lot-sizing methods, for instance, the heuristic ones, authors can find it quite difficult to select appropriate methods for solving their problems for each kind of application scenario. Therefore, the present study can provide useful knowledge to better support decision making in the lot-sizing domain.

Abstract
The domain of Production Planning and Control, or in a broader sence Production Management has been deserving a special and increasing attention by the companies, which intend to continuously achieve better results through continuous improvement, which also fits in the context of Industry 4.0. Companies tend to implement management systems with the purpose of achieving greater competitiveness and, consequently, greater sustainability in their sector. The selection of the appropriate production management system is a serious problem for the companies. The main objective of this study is to support companies in the correct choice of a Decision Support System. The method used to achieve the proposed objective consists on formulating a model for comparing functionalities and specifications, where selection of criteria were also defined and analyzed. Based on a large Company scenario, the model is applied to three production execution systems: SAP PP (Systems Applications and Products - Production Planning), Prodsmart and GenSYS. © Springer Nature Switzerland AG 2019.