Abstract
Study and conception of systems that help to the birth of new ideas, products and solutions has an ever increasing importance. One potentially attractive way is to use exist-ent creativity techniques of proven utility to generate new ideas that help companies' competitiveness. In this arti-cle, we resume the" Creative Information System and Creative Suport Systems(CSS), by presenting a concrete architetural proposal medeated by computer by Brute Thinking implementation. The study and design of sys-tems that help the birth of new ideas, products and solu-tions are growing in importance. A potentially attractive route is to use existing techniques for creativity and proven useful to generate new ideas that help the compet-itiveness of firms. In this article, we return to the concepts of "Creative System Information" and Creative Support Systems (CSS), presenting a concrete proposal for com-puter-mediated architecture for implementing the tech-nical Brute Thinking.

Abstract
This paper is about the development of 3D simulators for supplementary instruction in professional training with complex learning tasks and material, human and economic constraints. We present a theoretical framework describing and explaining how a simulator can support the fundamental interaction dynamics in learning settings (interaction with reality, with others and with the learner himself. We describe the development of an actual 3D simulator (for installing the engine in an F-16 fighter aircraft) and present its next phases. We discuss how our theoretical framework fits and explains the development phases of a 3D simulator to meet the intended learning outcomes and how it can help in the development of simulators with similar purposes.

Abstract
Research on virtual world use in education and training has focused on the current state of these technologies. In this paper, an overview of the current technological challenges that are faced in this context is provided, along with research directions towards the development of more advanced systems which can render virtual world use more widespread in education and training contexts.

Abstract

Abstract
Traditional approaches to virtual archaeology include dealing with research methods to capture information from heritage sites, creating models out of that information and how to present them to the public; these are intense technical procedures which might be too costly for some types of history or heritage-based projects. Virtual worlds allowed new types of models of/for heritage sites to be produced and disseminated at a fraction of the cost.Second Life®, and its open source counterpart, OpenSimulator, are virtual world platforms with user-generated content. 3D models are created in real time and instantly rendered for all visitors. This allows amateurs and researchers create their own virtual archaeology projects easily and with few costs, and to have the resulting models immediately available to a vast community of users. This article presents an overview of four different approaches to virtual archaeology projects that are present in these platforms and that have been publicly discussed and analyzed; in particular, the last type shows a novel approach to virtual archaeology which is not found in other platforms, and explains how researchers have managed to extend the concept to new areas and develop methodologies to incorporate the validation of historical accuracy to encompass these areas.

Abstract
Numerous animal model studies in the past decade have demonstrated that pharmacological elevation of cyclic AMP (cAMP) alone, or in combination with other treatments, can promote axonal regeneration after spinal cord injury. Elevation of cAMP via the phosphodiesterase 4 (PDE4) inhibitor, rolipram, decreases neuronal sensitivity to myelin inhibitors, increases growth potential and is neuroprotective. Rolipram's ability to cross the blood-brain barrier makes it a practical and promising treatment for CNS regeneration. However, several studies have questioned the efficacy of rolipram when given alone. The purpose of this investigation was to determine the effects of continuous administration of rolipram, given alone for 2 weeks, following a moderate T10 contusion injury in rat. Functional recovery was evaluated using the 21-point Basso, Beattie and Bresnahan (BBB) locomotor recovery scale and the beam walk. We used threedimensional (3D) instrumented gait analysis to allow detailed assessment and quantification of hindlimb motion. The amount of the damaged tissue and spared white matter was estimated stereologically. Our results show that administration of rolipram following acute spinal cord contusion results in improved motor performance at each time-point. Dynamic assessment of foot motion during treadmill walking revealed a significantly decreased external rotation during the entire step cycle after 8 weeks in rolipram-treated animals. Stereological analysis revealed no significant differences in lesion volume and length. By contrast, spared white matter was significantly higher in the group treated with rolipram. Our results suggest a therapeutic role for rolipram delivered alone following acute SCI.