Abstract
IntroductionWilson's disease (WD) is associated with a variety of movement disorders and progressive neurological dysfunction. The aim of this study was to correlate baseline brain magnetic resonance imaging (MRI) features with clinical phenotype and long-term outcomes in chronically treated WD patients.MethodsPatients were retrospectively selected from an institutional database. Two experienced neuroradiologists reviewed baseline brain MRI. Functional assessment was performed using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) scale, and disease severity was classified using the Global Assessment Scale for Wilson's Disease (GASWD).ResultsOf 27 patients selected, 14 were female (51.9%), with a mean (standard deviation [SD]) age at onset of 19.5 (7.1) years. Neurological symptoms developed in 22 patients (81.5%), with hyperkinetic symptoms being the most common (70.4%). Baseline brain MRI showed abnormal findings in 18 cases (66.7%), including T2 hyperintensities in 59.3% and atrophy in 29.6%. After a mean (SD) follow-up of 20.9 (11.0) years, WD patients had a mean score of 19.2 (10.2) on WHODAS 2.0 and 6.4 (5.7) on GASWD. The presence of hyperkinetic symptoms correlated with putaminal T2 hyperintensities (p = 0.003), putaminal T2 hypointensities (p = 0.009), and mesencephalic T2 hyperintensities (p = 0.009). Increased functional disability was associated with brain atrophy (p = 0.007), diffusion abnormalities (p = 0.013), and burden of T2 hyperintensities (p = 0.002). A stepwise regression model identified atrophy as a predictor of increased WHODAS 2.0 (p = 0.023) and GASWD (p = 0.007) scores.ConclusionsAtrophy and, to a lesser extent, deep T2 hyperintensity are associated with functional disability and disease severity in long-term follow-up of WD patients.

Abstract
Wind power is becoming an important source of electrical energy production. In an onshore wind farm (WF), the electrical energy is collected at a substation from different wind turbines through electrical cables deployed over ground ditches. This work considers the WF layout design assuming that the substation location and all wind turbine locations are given, and a set of electrical cable types is available. The WF layout problem, taking into account its lifetime and technical constraints, involves selecting the cables to interconnect all wind turbines to the substation and the supporting ditches to minimize the initial investment cost plus the cost of the electrical energy that is lost on the cables over the lifetime of the WF. It is assumed that each ditch can deploy multiple cables, turning this problem into a more complex variant of previously addressed WF layout problems. This variant turns the problem best fitting to the real case and leads to substantial gains in the total cost of the solutions. The problem is defined as an integer linear programming model, which is then strengthened with different sets of valid inequalities. The models are tested with four WFs with up to 115 wind turbines. The computational experiments show that the optimal solutions can be computed with the proposed models for almost all cases. The largest WF was not solved to optimality, but the final relative gaps are small.

Abstract
In recent years, as a result of population growth and the strong demand for energy resources, there has been an increase in greenhouse gas emissions. Thus, it is necessary to find solutions to reduce these emissions. This will make the use of electric vehicles (EV) more attractive and reduce the high dependency on internal combustion vehicles. However, the integration of electric vehicles will pose some challenges. For example, it will be necessary to increase the number of fast electric vehicle charging stations (FEVCS) to make electric mobility more attractive. Due to the high power levels involved in these systems, there are voltage drops that affect the voltage profile of some nodes of the distribution networks. This paper presents a methodology based on a genetic algorithm (GA) that is used to find the optimal location of charging stations that cause the minimum impact on the grid voltage profile. Two case studies are considered to evaluate the behavior of the distribution grid with different numbers of EV charging stations connected. From the results obtained, it can be concluded that the GA provides an efficient way to find the best charging station locations, ensuring that the grid voltage profile is within the regulatory limits and that the value of losses is minimized.

Abstract
Several sectors, such as agriculture and renewable energy systems, rely heavily on weather variables that are characterized by intermittent patterns. Many studies use regression and deep learning methods for weather forecasting to deal with this variability. This research employs regression models to estimate missing historical data and three different time horizons, incorporating long short-term memory (LSTM) to forecast short- to medium-term weather conditions at Quinta de Santa B & aacute;rbara in the Douro region. Additionally, a genetic algorithm (GA) is used to optimize the LSTM hyperparameters. The results obtained show that the proposed optimized LSTM effectively reduced the evaluation metrics across different time horizons. The obtained results underscore the importance of accurate weather forecasting in making important decisions in various sectors.

Abstract
Socioeconomic growth and population increase are driving a constant global demand for energy. Renewable energy is emerging as a leading solution to minimise the use of fossil fuels. However, renewable resources are characterised by significant intermittency and unpredictability, which impact their energy production and integration into the power grid. Forecasting models are increasingly being developed to address these challenges and have become crucial as renewable energy sources are integrated in energy systems. In this paper, a comparative analysis of forecasting methods for renewable energy production is developed, focusing on photovoltaic and wind power. A review of state-of-the-art techniques is conducted to synthesise and categorise different forecasting models, taking into account climatic variables, optimisation algorithms, pre-processing techniques, and various forecasting horizons. By integrating diverse techniques such as optimisation algorithms and pre-processing methods and carefully selecting the forecast horizon, it is possible to highlight the accuracy and stability of forecasts. Overall, the ongoing development and refinement of forecasting methods are crucial to achieve a sustainable and reliable energy future.

Abstract
Motivated by the imperative of sustainable practices, the wine industry is increasingly adopting renewable energy technologies to address environmental concerns and ensure its long-term viability amidst rising fossil fuel costs and greenhouse gas emissions. Hybrid renewable energy systems (HRES) have emerged as a solution to improve energy efficiency and mitigate the variability of renewable resources, allowing for better system load factors, greater stability of power supply, and optimized use of infrastructure. Therefore, this study aims to design a HRES that integrates solar and wind energy to sustainably fed an irrigation system in a favorable technical-economic context. This research presents a Mixed Integer Linear Programming (MILP) model that optimizes the profit generated by a grid-connected HRES over 20 years and obtains the optimal system sizing. The study focuses on the farm Quinta do Vallado, Portugal, and examines two distinct Cases. Over 20 years, the implementation of the hybrid system has resulted in savings of approximately 61%. © 2024 IEEE.