2013
Authors
Torres, A; Martins, FV;
Publication
Handbook of Research on Enterprise 2.0: Technological, Social, and Organizational Dimensions
Abstract
The chapter is conceptual, based on analysis and synthesis of social network theory and e-consumer literature. Despite a broad spectrum of disciplines that investigate social networks and the interest of marketing practitioners in the consequences of social networks, there are still areas open for research into networked-consumer behavior in marketing. Based on previous theoretical and empirical research, this study examines and discusses the influence of social network structure and ties in matched dyads, recommendation diffusion, social contagion and co-consumption influence, and individual motivations to spread market information. The chapter proposes a theory of matched dyadic ties in close networks of connections as a proxy for information about the potential market that is difficult and expensive for businesses to measure or access directly. © 2014, IGI Global.
2013
Authors
Gomes, EF; Bentley, PJ; Coimbra, M; Pereira, E; Deng, Y;
Publication
HEALTHINF 2013 - Proceedings of the International Conference on Health Informatics
Abstract
In this paper we describe a methodology for heart sound classification and results obtained at PASCAL Classifying Heart Sounds Challenge. The results of competing methodologies are shown. The approach has two steps: segmentation and classification of heart sounds. We also describe the data collection procedure.
2013
Authors
Osorio, A;
Publication
ECONOMICS LETTERS
Abstract
In this paper we relax the Colonel Blotto game assumption that for a given battle the player who allocates the higher measure of resources wins that battle. We assume that for a given battle, the Colonel who allocates the higher measure of resources is more likely to win. We have a simpler model for which we are able to compute all Nash equilibria in pure strategies for any valuations profile that players might have, something that is not possible for the original Blotto game.
2013
Authors
Bassaganyas, L; Beà, S; Escaramís, G; Tornador, C; Salaverria, I; Zapata, L; Drechsel, O; Ferreira, PG; Rodriguez Santiago, B; Tubio, JMC; Navarro, A; Martín García, D; López, C; Martínez Trillos, A; López Guillermo, A; Gut, M; Ossowski, S; López Otín, C; Campo, E; Estivill, X;
Publication
Leukemia
Abstract
2013
Authors
Ferreira, PG; Patalano, S; Chauhan, R; Ffrench Constant, R; Gabaldon, T; Guigo, R; Sumner, S;
Publication
GENOME BIOLOGY
Abstract
Background: Understanding how alternative phenotypes arise from the same genome is a major challenge in modern biology. Eusociality in insects requires the evolution of two alternative phenotypes - workers, who sacrifice personal reproduction, and queens, who realize that reproduction. Extensive work on honeybees and ants has revealed the molecular basis of derived queen and worker phenotypes in highly eusocial lineages, but we lack equivalent deep-level analyses of wasps and of primitively eusocial species, the latter of which can reveal how phenotypic decoupling first occurs in the early stages of eusocial evolution. Results: We sequenced 20 Gbp of transcriptomes derived from brains of different behavioral castes of the primitively eusocial tropical paper wasp Polistes canadensis. Surprisingly, 75% of the 2,442 genes differentially expressed between phenotypes were novel, having no significant homology with described sequences. Moreover, 90% of these novel genes were significantly upregulated in workers relative to queens. Differential expression of novel genes in the early stages of sociality may be important in facilitating the evolution of worker behavioral complexity in eusocial evolution. We also found surprisingly low correlation in the identity and direction of expression of differentially expressed genes across similar phenotypes in different social lineages, supporting the idea that social evolution in different lineages requires substantial de novo rewiring of molecular pathways. Conclusions: These genomic resources for aculeate wasps and first transcriptome-wide insights into the origin of castes bring us closer to a more general understanding of eusocial evolution and how phenotypic diversity arises from the same genome.
2013
Authors
Lappalainen, T; Sammeth, M; Friedländer, MR; ‘t Hoen, PAC; Monlong, J; Rivas, MA; Gonzàlez-Porta, M; Kurbatova, N; Griebel, T; Ferreira, PG; Barann, M; Wieland, T; Greger, L; van Iterson, M; Almlöf, J; Ribeca, P; Pulyakhina, I; Esser, D; Giger, T; Tikhonov, A; Sultan, M; Bertier, G; MacArthur, DG; Lek, M; Lizano, E; Buermans, HPJ; Padioleau, I; Schwarzmayr, T; Karlberg, O; Ongen, H; Kilpinen, H; Beltran, S; Gut, M; Kahlem, K; Amstislavskiy, V; Stegle, O; Pirinen, M; Montgomery, SB; Donnelly, P; McCarthy, MI; Flicek, P; Strom, TM; The Geuvadis Consortium,; Lehrach, H; Schreiber, S; Sudbrak, R; Carracedo,; Antonarakis, SE; Häsler, R; Syvänen, A; van Ommen, G; Brazma, A; Meitinger, T; Rosenstiel, P; Guigó, R; Gut, IG; Estivill, X; Dermitzakis, ET;
Publication
NATURE
Abstract
Genome sequencing projects are discovering millions of genetic variants in humans, and interpretation of their functional effects is essential for understanding the genetic basis of variation in human traits. Here we report sequencing and deep analysis of messenger RNA and microRNA from lymphoblastoid cell lines of 462 individuals from the 1000 Genomes Project-the first uniformly processed high-throughput RNA-sequencing data from multiple human populations with high-quality genome sequences. We discover extremely widespread genetic variation affecting the regulation of most genes, with transcript structure and expression level variation being equally common but genetically largely independent. Our characterization of causal regulatory variation sheds light on the cellular mechanisms of regulatory and loss-of-function variation, and allows us to infer putative causal variants for dozens of disease-associated loci. Altogether, this study provides a deep understanding of the cellular mechanisms of transcriptome variation and of the landscape of functional variants in the human genome.
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