Abstract
Sectorization problems, also known as districting or territory design, deal with grouping a set of previously defined basic units, such as points or small geographical areas, into a fixed number of sectors or responsibility areas. Usually, there are multiple criteria to be satisfied regarding the geographic characteristics of the territory or the planning purposes. This work addresses a case study of parcel delivery services in the region of Porto, Portugal. Using knowledge about the daily demand in each basic unit (7-digit postal code), the authors analysed data and used it to simulate dynamically new daily demands according to the relative frequency of service in each basic unit and the statistical distribution of the number of parcels to be delivered in each basic unit. The sectorization of the postal codes is solved independently considering two objectives (equilibrium and compactness) using Non-dominated Sorting Genetic Algorithm-II (NSGA-II) implemented in Python.

Abstract
The growing use of data-driven decision systems based on Artificial Intelligence (AI) by governments, companies and social organizations has given more attention to the challenges they pose to society. Over the last few years, news about discrimination appeared on social media, and privacy, among others, highlighted their vulnerabilities. Despite all the research around these issues, the definition of concepts inherent to the risks and/or vulnerabilities of data-driven decision systems is not consensual. Categorizing the dangers and vulnerabilities of data-driven decision systems will facilitate ethics by design, ethics in design and ethics for designers to contribute to responsibleAI. Themain goal of thiswork is to understand which types of AI risks/ vulnerabilities are Ethical and/or Technological and the differences between human vs machine classification. We analyze two types of problems: (i) the risks/ vulnerabilities classification task by humans; and (ii) the risks/vulnerabilities classification task by machines. To carry out the analysis, we applied a survey to perform human classification and the BERT algorithm in machine classification. The results show that even with different levels of detail, the classification of vulnerabilities is in agreement in most cases.

Abstract
The full realization of the potential of a technology requires good understanding of its imple-mentation. During implementations, lack of compatibility between technology and its adopters require dynamic sequences of alignment. This process is understood to be central to the success in technology assimilation. This paper proposes a configurational model to explain and predict the alignment process during technology implementations, derived from a multiple case research of the implementation of a retinopathy screening program in networks of healthcare providers. It builds on and expands previous research capturing in a holistic way the alignment process and its nature of adaptation over time.

Abstract
Supplier selection for strategic items requires a comprehensive framework dealing with qualitative and quantitative aspects of a company's competitive priorities and supply risk, decision scope, and uncertainty. In order to address these aspects, this study aims to tackle supplier selection for strategic items with a multi-sourcing, taking into account multi-criteria, incorporating uncertainty of decision-makers judgment and supplier-buyer parameters, and integrating with inventory management which the past studies have not addressed well. We develop a novel two-phase solution approach based on integrated multi-criteria decision -making (MCDM) and multi-objective simulation-optimization (S-O). First, MCDM methods, including fuzzy AHP and interval TOPSIS, are applied to calculate suppliers' scores, incorporating uncertain decision makers' judgment. S-O then combines the (quantitative) cost-related criteria and considers supply disruptions and uncertain supplier-buyer parameters. By running this approach on data generated based on previous studies, we evaluate the impact of the decision maker's and the objective's weight, which are considered important in supplier selection.

Abstract
This article addresses the Production Routing Problem (PRP), which consists of determining, in an integrated way, production and inventory planning, and vehicle routing to minimize the costs involved. In the problem, a plant is responsible for producing several types of products to meet the known demand of a set of customers using a homogeneous fleet of vehicles over the planning horizon. In the literature, evolutionary approaches have not been explored in depth for the PRP, specifically for the problem with multiple products. Thus, this work mitigates this gap, presenting a novel Memetic Algorithm and testing its effectiveness on randomly generated sets of instances, comparing the results obtained with a commercial optimization solver. In our solution approach, several classic operators from the literature were implemented. Furthermore, we propose four novel genetic operators. In addition, we evaluated the proposed method's performance in classical instances of literature considering a single item. The computational experiments were carried out to assess the impact of the numerous parameter combinations involving the metaheuristic, and, from statistical analyses, we evidence the proposed technique's robustness. Computational experiments showed that our proposed method outperforms the commercial solver Gurobi in determining feasibly high-quality solutions, mainly on large instances for the PRP with multiple items.

Abstract
Background and aims: currently, most endoscopy software only provides limited statistics of past procedures, while none allows patterns to be extrapolated. To overcome this need, the authors applied business analytic models to pre-dict future demand and the need for endoscopists in a ter-tiary hospital Endoscopy Unit. Methods: a query to the endoscopy database was per-formed to retrieve demand from 2015 to 2021. The graphi-cal inspection allowed inferring of trends and seasonality, perceiving the impact of the COVID-19 pandemic, and se-lecting the best forecasting models. Considering COVID-19's impact in the second quarter of 2020, data for esoph-agogastroduodenoscopy (EGD) and colonoscopy was estimated using linear regression of historical data. The actual demand in the first two quarters of 2022 was used to validate the models. Results: during the study period, 53,886 procedures were requested. The best forecasting models were: a) simple sea-sonal exponential smoothing for EGD, colonoscopy and percutaneous endoscopic gastrostomy (PEG); b) double ex-ponential smoothing for capsule endoscopy and deep en-teroscopy; and c) simple exponential smoothing for endo-scopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS). The mean average percent-age error ranged from 6.1 % (EGD) to 33.5 % (deep en - teroscopy). Overall, 8,788 procedures were predicted for 2022. The actual demand in the first two quarters of 2022 was within the predicted range. Considering the usual time allocation for each technique, 3.2 full-time equivalent en-doscopists (40 hours-dedication to endoscopy) will be re-quired to perform all procedures in 2022. Conclusions: the incorporation of business analytics into the endoscopy software and clinical practice may enhance resource allocation, improving patient-focused deci-sion-making and healthcare quality.