Abstract
Polyethylene terephthalate (PET) preforms are massively produced nowadays with the purpose of producing food and beverages packaging and liquid containers. Some varieties of these preforms are produced as multilayer structures, where very thin inner film(s) act as a barrier for nutrients leakage. The knowledge of the thickness of this thin inner layer is important in the production line. The quality control of preforms production requires a fast approach and normally the thickness control is performed by destructive means out of the production line. A spectral domain optical coherence tomography (SD-OCT) method was proposed to examine the thin layers in real time. This paper describes a non-destructive approach and all required signal processing steps to characterize the thin inner layers and also to improve the imaging speed and the signal to noise ratio. The algorithm was developed by using graphics processing unit (GPU) with computer unified device architecture (CUDA). This GPU-accelerated white light interferometry technique non-destructively assesses the samples and has high imaging speed advantage, overcoming the bottlenecks in PET performs quality control.

Abstract
A spectral calibration technique, a data processing method and the importance of calibration and re-sampling methods for the spectral domain optical coherence tomography system were numerically studied, targeted to optical coherence tomography (OCT) signal processing implementation under graphics processing unit (GPU) architecture. Accurately, assigning the wavelength to each pixel of the detector is of paramount importance to obtain high quality images and increase signal to noise ratio (SNR). High quality imaging can be achieved by proper calibration methods, here performed by phase calibration and interpolation. SNR was assessed employing two approaches, single spectrum moving window averaging and consecutive spectra data averaging, to investigate the optimized method and factor for background noise reduction. It was demonstrated that the consecutive spectra averaging had better SNR performance. © 2012 The Author(s).

Abstract
High-precision dosimeters are needed in brachytherapy treatments to ensure safe operation and adequate working conditions, to assess the correspondence between treatment planning and dose delivery, as well as to monitor the radiation dose received by patients. In this paper we present the development of a multi-sensor dosimeter platform targeted for brachytherapy environments. The performance of different scintillating materials response is assessed. The emission bands of most common scintillator materials used in ionizing radiation detection are typically below 550 nm, thus they may be prone to stem effect response. To avoid this effect we propose the use of scintillators with longer wavelength emission. Samples of neodymium doped glasses are evaluated as new infrared radioluminescent scintillators for real-time dosimeters, namely lithium lead boron silver (LLB4Ag) and lithium bismuth boron silver (LBiB4Ag) glasses. Their response is compared with the response of organic scintillator BCF-60 with a 530nm response.

Abstract
There are several factors such as the chosen optical source, central wavelength, spectral bandwidth, spectrometer optical components and the detector specifications that affect the overall performance of a spectral domain optical coherence tomography (SD-OCT) imaging system. Among these factors a good design and implementation of the spectrometer is of paramount importance as it directly affects the system resolution, sensitivity fall-off, maximum imaging depth, SNR and in general the system performance. This study demonstrates the design steps and some considerations during the design of a spectrometer. The imaging performance of this design is assessed. The obtained experimental results prove an improvement of the overall performance of the common path SD-OCT imaging system and agree with the expected outcome from the design stage.

Abstract
Optical Tweezers (OTs) have been widely applied in Biology, due to their outstanding focusing abilities, which make them able to exert forces on micro-sized particles. The magnitude of such forces (pN) is strong enough to trap their targets. However, the most conventional OT setups are based on complex configurations, being associated with focusing difficulties with biologic samples. Optical Fiber Tweezers (OFTs), which consist in optical fibers with a lens in one of its extremities are valuable alternatives to Conventional Optical Tweezers (COTs). OFTs are flexible, simpler, low-cost and easy to handle. However, its trapping performance when manipulating biological and complex structures remains poorly characterized. In this study, we experimentally characterized the optical trapping of a biological cell found within a culture of rodent glial neuronal cells, using a polymeric lens fabricated through a photo-polymerization method on the top of a fiber. Its trapping performance was compared with two synthetic microspheres (PMMA, polystyrene) and two simple cells (a yeast and a Drosophila Melanogaster cell). Moreover, the experimental results were also compared with theoretical calculations made using a numerical model based on the Finite Differences Time Domain. It was found that, although the mammalian neuronal cell had larger dimensions, the magnitude of forces exerted on it was the lowest among all particles. Our results allowed us to quantify, for the first time, the complexity degree of manipulating such "demanding" cells in comparison with known targets. Thus, they can provide valuable insights about the influence of particle parameters such as size, refractive index, homogeneity degree and nature (biologic, synthetic). Furthermore, the theoretical results matched the experimental ones which validates the proposed model.

Abstract
Optical coherence tomography (OCT) systems have huge potential for applications beyond the traditional ophthalmology as a general-purpose medical instrument for optical biopsy. The widening of the range of applications is expected to significantly increase production volume and, consequently, puts pressure on unit cost. This trend calls for a flexible and miniaturized system fabricated in a batch process. In this paper, the different OCT configurations are compared for suitability in such an implementation. The required flexibility favors operation in the spectral domain, using a broadband light source in combination with a spectrometer, while the miniaturization and low unit-cost in batch fabrication can be achieved using silicon micro-system technologies. The feasibility of miniaturizing OCT components has already been demonstrated, amongst others a beam splitter using 45 degrees saw dicing of a glass substrate and appropriate thin-film coating the integration of the essential components into a single OCT microsystem remains a challenge. In this paper, the wafer-level fabrication of a Michelson interferometer for a miniaturized OCT system is presented, using an improved 45 degrees saw dicing process, which is suitable for wafer-level co-integration of also the other components of the OCT microsystem.