Abstract
Currently, radiologists face an excessive workload, which leads to high levels of fatigue, and consequently, to undesired diagnosis mistakes. Decision support systems can be used to prioritize and help radiologists making quicker decisions. In this sense, medical content-based image retrieval systems can be of extreme utility by providing well-curated similar examples. Nonetheless, most medical content-based image retrieval systems work by finding the most similar image, which is not equivalent to finding the most similar image in terms of disease and its severity. Here, we propose an interpretability-driven and an attention-driven medical image retrieval system. We conducted experiments in a large and publicly available dataset of chest radiographs with structured labels derived from free-text radiology reports (MIMIC-CXR-JPG). We evaluated the methods on two common conditions: pleural effusion and (potential) pneumonia. As ground-truth to perform the evaluation, query/test and catalogue images were classified and ordered by an experienced board-certified radiologist. For a profound and complete evaluation, additional radiologists also provided their rankings, which allowed us to infer inter-rater variability, and yield qualitative performance levels. Based on our ground-truth ranking, we also quantitatively evaluated the proposed approaches by computing the normalized Discounted Cumulative Gain (nDCG). We found that the Interpretability-guided approach outperforms the other state-of-the-art approaches and shows the best agreement with the most experienced radiologist. Furthermore, its performance lies within the observed inter-rater variability.

Abstract
Semantic segmentation consists of classifying each pixel according to a set of classes. This process is particularly slow for high-resolution images, which are present in many applications, ranging from biomedicine to the automotive industry. In this work, we propose an algorithm targeted to segment high-resolution images based on two stages. During stage 1, a lower-resolution interpolation of the image is the input of a first neural network, whose low-resolution output is resized to the original resolution. Then, in stage 2, the probabilities resulting from stage 1 are divided into contiguous patches, with less confident ones being collected and refined by a second neural network. The main novelty of this algorithm is the aggregation of the low-resolution result from stage 1 with the high-resolution patches from stage 2. We propose the U-Net architecture segmentation, evaluated in six databases. Our method shows similar results to the baseline regarding the Dice coefficient, with fewer arithmetic operations.

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Abstract