Abstract
This study seeks to answer the following research question: "What factors can explain the number of patent filing requests made by residents in Brazil at patent offices in Brazil, the United States, Europe, and triadic patent families?". The methods used in this research are quantitative, using big data from private and public investments in Science and Technology, and about patent deposit numbers in Brazil from 2000 to 2017. A model of linear regression was performed and explains how these investments in Science and Technology influence patent deposit numbers. The results of this research study point towards the importance of universities, up and beyond the traditional training and education aspect of university activity. The importance of public and private innovation investments is also shown to be important. This study shows that the patent registrations in the different regions under analysis are affected by different factors. There is thus no single formula towards the creation of innovation output and governments would do well to continue to invest in higher education while also investing in public research and development activities. Additionally, and not least important, private entities should be continually encouraged to make innovation investments and favourable government policies need to thus exist for this to happen. Finally, the low numbers regarding patent filings in Brazil may be linked to institutional deficiencies in the country. Patent breaches may be difficult to punish, and the judicial system may be slow and untrustworthy, compared to the United States and to Europe-leading to diminished patent registrations in Brazil. A set of implications and recommendations for policy derived from this study and will be strategic for policymakers.

Abstract
Micro and Small Enterprises have emerged as an important alternative for the generation of jobs and income, mainly in countries that present serious market failures for the creation of productive jobs. However, the lack of commercial and managerial skills, inadequate access to markets, as well as the absence of an entrepreneurial culture has led to a high level of failure in these ventures. Additionally, the current competitive scenario has been increasingly based on innovation, responsible for the destruction of traditional competitive barriers, requiring a new approach on the part of Micro and Small Enterprises to be able to remain in the market sustainably. Accordingly, this research aims to determine the influence that business management has on the degree of innovation of Brazilian Micro and Small Enterprises through Structural Equation Modeling. As a theoretical contribution, the present investigation may point to statistical evidence that may support a causal inference between business management, understood in the present investigation as a decision process on strategic and operational aspects of a business, and the innovation capacity of companies. Furthermore, this research can provide important practical contributions by highlighting the relevance that business management has for Micro and Small Enterprises, also pointing to the need for Micro and Small Enterprises to adopt systematic business management practices that raise their potential concerning the development of innovations and the maintenance of a sustainable competitive position.

Abstract
Micro and Small Enterprises have assumed an important strategic role for the economic and social development of Brazil, representing about 99% of all business establishments and contributing to the generation of 55.3% of all formal jobs in the country. However, these ventures have faced a series of restrictions on entrepreneurial activity, such as low government support, high taxes, and excessive bureaucracy. In this adverse context, innovation assumes a significant mediation role for increasing business performance and, consequently, maintaining the permanence of these ventures in the market. Accordingly, the present investigation aimed to identify the degree of innovation, the main obstacles and facilitators of innovation, as well as the types of innovation prevalent in Brazilian Micro and Small Enterprises through a systematic literature review. The literature review included 21 articles extracted from the Web of Science, Scopus, Scielo, and Spell databases. In general, the analyzed literature points out that innovation in these ventures is the result of simple actions, such as imitation and the acquisition of technology from third parties, and that the degree of innovation is low, prevailing in the types of innovation in Products and Marketing. The main barriers highlighted were related to the lack of resources, precarious managerial and commercial capacities, and shortages of qualified labor, while the factors that facilitate innovation are related to the support of government programs and the organization of Micro and Small Enterprises in productive arrangements.

Abstract

Abstract
The European Structural and Investment Funds (ESIF) represent the main instrument of European Cohesion Policy to sustain territorial development and to eliminate regional disparities between the EU member states. The study of the impacts of ESIF on the economic growth and development of EU members has gained increasing attention in the academic community, and there has been significant scientific production on this topic. This study consists of a bibliometric analysis of articles published in the period from 2011 to 2020 and indexed in two of the main scientific databases: Web of Science (WoS) and Scopus. The results of the bibliometric analysis point to relevant trends on the subject, such as the growing number of publications over the years; the great concentration of studies applied in Central and Eastern European (CEE) countries, namely Romania; and the current interest of researchers in important topics associated with European funds, such as the competitiveness and innovation of SMEs, climate change, economic impact of global crises, sustainable development, institutional capacity of organisations, and cross-border cooperation.

Abstract
The tradition of wine production and consumption in Portugal is widely spread since the country presents climatic and territorial characteristics which have made wine-making an important strategic sector. In addition, the essence of the wine industry has led to greater tourism, thus enhancing the growth of enotourism. Given the importance of the wine production sector in the national context, as well as the potential of Industry 4.0 to stimulate improvements both in efficiency and competitiveness, the objective of this work is to achieve a better understanding of how Industry 4.0 and its key features, namely simulation, can influence wine production and enotourism.