Abstract
This paper introduces a mathematical model designed to optimise the operation of natural gas distribution networks, considering the injection of hydrogen in multiple nodes. The model is designed to optimise the quantity of hydrogen injected to maintain pressure, gas flows, and gas quality indexes (Wobbe index (WI) and higher heating value (HHV)) within admissible limits. This study also presents the maximum injection allowable of hydrogen correlated with the gas quality index variation. The model has been applied to a case study of a gas network with four distinct scenarios and implemented using Python. The findings of the case study quantify the maximum permitted volume of hydrogen in the network, the total savings in natural gas, and the reduction in carbon dioxide emissions. Lastly, a sensitivity analysis of injected hydrogen as a function of the Wobbe index (WI) and Higher Heating Value (HHV) limits relaxation.

Abstract
The integration of electric vehicles is paramount to the electrification of the transport sector, supporting the energy transition. The charging process of electric vehicles can be perceived as a controllable load and targeted with price or incentive-based programs. Demand-side management can optimize charging station performance and integrate renewable energy generation through electrical energy storage. Data flowing through charging stations can be used in computational approaches to solve open challenges and create new services, such as a dynamic pricing strategy, where the charging tariff depends on operating conditions. This work presents a data-driven service that optimizes day-ahead charging tariffs with a bilevel optimization problem and develops a case study around a large-scale pilot. The impact of photovoltaics and battery storage on the dynamic pricing scheme was assessed. A dynamic pricing strategy was found to benefit self-consumption and self-sufficiency of the charging station, increasing over 4 percentage points in some cases.

Abstract
Intervention studies have been explored to identify actions to effectively remediate indoor environmental quality (IEQ) problems and to improve people's health, well-being, comfort, and productivity. This study assessed a comprehensive set of IEQ indicators related to ventilation, air pollution, thermal comfort, illuminance, and noise for the first time in Portuguese office buildings. The purpose was to derive evidence-based corrective measures for a further environmental intervention program. The study monitored and surveyed 15 open-space offices from six modern office buildings in Porto (Portugal) during a workday between September and December 2022. Illuminance was of most concern among the assessed IEQ indicators since the measured levels were below the minimum limit required in 27% of the evaluated workplaces. For CO2, although mean concentrations were below 1000 ppm, absolute values exceeding that level were consistently registered in 20% of the offices during the afternoon period. Mean levels of PM2.5, PM10, and ultrafine particles exceeding the WHO guidelines were found in 13%, 7%, and 7% of the offices, respectively. The assessed thermal comfort levels were typically neutral, corresponding to an estimated mean of 6% of dissatisfied people. Based on the findings, an intervention plan was designed to be implemented in the further stages of this work. The priority interventions to test include relocation of printers (PM source removal), optimisation of ventilation rates (using real-time data from CO2 sensors), adjustment of desk positions to improve illuminance, and introduction of indoor plants.

Abstract
This article presents a solution for a work related to the curricular unit Energy Markets and Regulation within the scope of PDEEC-Doctoral Program in Electrical and Computer Engineering. The task consists of evaluating optimal dispatch and market pool results (symmetric and asymmetric) for different periods. To check the technical feasibility of implementing the dispatch recommended by the pool market, a DC power flow is analyzed, by accounting for a network with six busbars. Results show that in some periods of higher demand, there could be an overload in some transmission lines of the considered network for certain results of market dispatch. © 2024, Universidade do Porto - Faculdade de Engenharia. All rights reserved.

Abstract
Methylation is considered one of the proteins' most important post-translational modifications (PTM). Plasticity and cellular dynamics are among the many traits that are regulated by methylation. Currently, methylation sites are identified using experimental approaches. However, these methods are time-consuming and expensive. With the use of computer modelling, methylation sites can be identified quickly and accurately, providing valuable information for further trial and investigation. In this study, we propose a new machine-learning model called MeSEP to predict methylation sites that incorporates both evolutionary and structural-based information. To build this model, we first extract evolutionary and structural features from the PSSM and SPD2 profiles, respectively. We then employ Extreme Gradient Boosting (XGBoost) as the classification model to predict methylation sites. To address the issue of imbalanced data and bias towards negative samples, we use the SMOTETomek-based hybrid sampling method. The MeSEP was validated on an independent test set (ITS) and 10-fold cross-validation (TCV) using lysine methylation sites. The method achieved: an accuracy of 82.9% in ITS and 84.6% in TCV; precision of 0.92 in ITS and 0.94 in TCV; area under the curve values of 0.90 in ITS and 0.92 in TCV; F1 score of 0.81 in ITS and 0.83 in TCV; and MCC of 0.67 in ITS and 0.70 in TCV. MeSEP significantly outperformed previous studies found in the literature. MeSEP as a standalone toolkit and all its source codes are publicly available at https://github.com/arafatro/MeSEP.

Abstract
This paper proposes to extend the fast-decoupled state estimation formulation to bring its well-known efficiency and benefits to the processing of networks with embedded FACTS devices. The proposed method approaches shunt-, series-, and shunt -series -type devices. The controller parameters are included as new active or reactive state variables, while controlled quantity values are included in the metering scheme of the decoupled approach. From the electrical model adopted for each device, the extended formulation is presented, and a modified fast-decoupled method is devised, seeking to ensure accuracy and impart robustness to the iterative solution. Simulation results conducted throughout the IEEE 30 -bus test system with distinct types of FACTS devices are used to validate and evaluate the performance of the proposed decoupled approaches.