Abstract
The role of new technologies such as additive manufacturing and blockchain technology in designing and implementing circular economy ecosystems is not a trivial issue. This study aimed to understand if blockchain technology can be an enabler tool for developing additive symbiotic networks. A real case study was developed regarding a circular economy ecosystem in which a fused granular fabrication 3D printer is used to valorize polycarbonate waste. The industrial symbiosis network comprised four stakeholders: a manufacturing company that produces polycarbonate waste, a municipality service responsible for the city waste management, a start-up holding the 3D printer, and a non-profit store. It was identified a set of six requirements to adopt the blockchain technology in an additive symbiotic network, bearing in mind the need to have a database to keep track of the properties of the input material for the 3D printer during the exchanges, in addition to the inexistence of mechanisms of trust or cooperation between well-established industries and the additive manufacturing industry. The findings suggested a permissioned blockchain to support the implementation of the additive symbiotic network, namely, to enable the physical transactions (quantity and quality of waste material PC sheets) and monitoring and reporting (additive manufacturing technology knowledge and final product's quantity and price).Future research venues include developing blockchain-based systems that enhance the development of ad-ditive symbiotic networks.

Abstract
Nowadays, Virtual Reality (VR) and Augmented Reality (AR) systems are not exclusively associated with the gaming industry. Their potential is also useful for other business areas such as healthcare, automotive, and educational domains. Companies need to accompany technological advances and enhance their business processes and thus, the adoption of VR or AR technologies could be advantageous in reducing resource usage or improving the overall efficiency of processes. However, before implementing these technologies, companies must be aware of potential cyberattacks and security risks to which these systems are subject. This study presents a survey of attacks related to VR and AR scenarios and their risk assessment when considering healthcare, automation, education, and gaming industries. The main goal is to make companies aware of the possible cyberattacks that can affect the devices and their impact on their business domain. © 2023 IEEE.

Abstract

Abstract
The advent of 6G networks is anticipated to introduce a myriad of new technology enablers, including heterogeneous radio, RAN softwarization, multi-vendor deployments, and AI-driven network management, which is expected to broaden the existing threat landscape, demanding for more sophisticated security controls. At the same time, privacy forms a fundamental pillar in the EU development activities for 6G. This decentralized and globally connected environment necessitates robust privacy provisions that encompass all layers of the network stack. In this paper, we present PRIVATEER’s approach for enabling “privacy-first” security enablers for 6G networks. PRIVATEER aims to tackle four major privacy challenges associated with 6G security enablers, i.e., i) processing of infrastructure and network usage data, ii) security-aware orchestration, iii) infrastructure and service attestation and iv) cyber threat intelligence sharing. PRIVATEER addresses the above by introducing several innovations, including decentralised robust security analytics, privacy-aware techniques for network slicing and service orchestration and distributed infrastructure and service attestation mechanisms. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

Abstract
IntroductionPerinatal asphyxia is one of the most frequent causes of neonatal mortality, affecting approximately four million newborns worldwide each year and causing the death of one million individuals. One of the main reasons for these high incidences is the lack of consensual methods of early diagnosis for this pathology. Estimating risk-appropriate health care for mother and baby is essential for increasing the quality of the health care system. Thus, it is necessary to investigate models that improve the prediction of perinatal asphyxia. Access to the cardiotocographic signals (CTGs) in conjunction with various clinical parameters can be crucial for the development of a successful model. ObjectivesThis exploratory work aims to develop predictive models of perinatal asphyxia based on clinical parameters and fetal heart rate (fHR) indices. MethodsSingle gestations data from a retrospective unicentric study from Centro Hospitalar e Universitario do Porto de Sao Joao (CHUSJ) between 2010 and 2018 was probed. The CTGs were acquired and analyzed by Omniview-SisPorto, estimating several fHR features. The clinical variables were obtained from the electronic clinical records stored by ObsCare. Entropy and compression characterized the complexity of the fHR time series. These variables' contribution to the prediction of asphyxia perinatal was probed by binary logistic regression (BLR) and Naive-Bayes (NB) models. ResultsThe data consisted of 517 cases, with 15 pathological cases. The asphyxia prediction models showed promising results, with an area under the receiver operator characteristic curve (AUC) >70%. In NB approaches, the best models combined clinical and SisPorto features. The best model was the univariate BLR with the variable compression ratio scale 2 (CR2) and an AUC of 94.93% [94.55; 95.31%]. ConclusionBoth BLR and Bayesian models have advantages and disadvantages. The model with the best performance predicting perinatal asphyxia was the univariate BLR with the CR2 variable, demonstrating the importance of non-linear indices in perinatal asphyxia detection. Future studies should explore decision support systems to detect sepsis, including clinical and CTGs features (linear and non-linear).

Abstract
Regulated exocytosis consists of the fusion between vesicles and the plasma membranes, leading to the formation of a narrow fusion pore through which secretions exit the vesicle lumen into the extracellular space. An increase in the cytosolic concentration of free Ca2+ ([Ca2+](i)) is considered the stimulus of this process. However, whether this mechanism can be preserved in a simplified system of membrane lawns with docked secretory vesicles, devoid of cellular components, is poorly understood. Here, we studied peptide discharge from individual secretory vesicles docked at the plasma membrane, prepared from primary endocrine pituitary cells (the lactotrophs), releasing hormone prolactin. To label secretory vesicles, we transfected lactotrophs to express the fluorescent atrial natriuretic peptide (ANP.emd), previously shown to be expressed in and released from prolactin-containing vesicles. We used stimulating solutions containing different [Ca2+] to evoke vesicle peptide discharge, which appeared similar in membrane lawns and in intact stimulated lactotrophs. All vesicles examined discharged peptides in a subquantal manner, either exhibiting a unitary or sequential time course. In the membrane lawns, the unitary vesicle peptide discharge was predominant and slightly slower than that recorded in intact cells, but with a shorter delay with respect to the stimulation onset. This study revealed directly that Ca2+ triggers peptide discharge from docked single vesicles in the membrane lawns with a half-maximal response of similar to 8 mu M [Ca2+], consistent with previous whole-cell patch-clamp studies in endocrine cells where the rapid component of exocytosis, interpreted to represent docked vesicles, was fully activated at <10 mu M [Ca2+]. Interestingly, the sequential subquantal peptide vesicle discharge indicates that fluctuations between constricted and dilated fusion pore states are preserved in membrane lawns and that fusion pore regulation appears to be an autonomously controlled process.