Abstract
Patient-specific surgical predictions of Breast Conserving Therapy, through mechano-biological simulations, could inform the shared decision making process between clinicians and patients by enabling the impact of different surgical options to be visualised. We present an overview of our processing workflow that integrates MR images and three dimensional optical surface scans into a personalised model. Utilising an interactively generated surgical plan, a multi-scale open source finite element solver is employed to simulate breast deformity based on interrelated physiological and biomechanical processes that occur post surgery. Our outcome predictions, based on the pre-surgical imaging, were validated by comparing the simulated outcome with follow-up surface scans of four patients acquired 6 to 12 months post-surgery. A mean absolute surface distance of 3.3mm between the follow-up scan and the simulation was obtained.

Abstract
Surgery planing of breast cancer interventions is gaining importance among physicians, who recognize value in discussing the possible aesthetic outcomes of surgery with patients. Research is been propelled to create patient-specific breast models, but breast image registration algorithms are still limited, particularly for the purpose of matching pre- and post-surgical data of patient's breast surfaces. Yet, this is a fundamental task to learn prediction models of breast healing process after surgery. In this paper, a coarse-to-fine registration strategy is proposed to match breast surface data acquired before and after surgery. Methods are evaluated in their ability to register surfaces in an anatomical reliable way, and results suggest proper alignment adequated to be used as input to train deformable models.

Abstract
The medical procedures related with the Breast Cancer Conservative Treatment (BCCT) have evolved towards the usage of affordable and practical tools, along with the recent inclusion of volumetric information of the breast. A richer three-dimensional (3D) model of the female torso allows, for instance, improvement of the evaluation the aesthetic outcome of BCCT and the surgery planning. The standard 3D reconstruction methods often fail to model objects of interest using highly misaligned views. In this work, a Tessellation-based coarse registration method is proposed, based on robust keypoints extraction from RGB-D data using the Delaunay Triangulation (DT) principle. With this method, it is possible to reconstruct female torso data with detail using only 3 views, in feasible time. Structures such as the nipples and the breast contour were correctly reconstructed and a highly correlated with reference models.

Abstract

Abstract
Breast cancer treatments can have a negative impact on breast aesthetics, in case when surgery is intended to intersect tumor. For many years mastectomy was the only surgical option, but more recently breast conserving surgery (BCS) has been promoted as a liable alternative to treat cancer while preserving most part of the breast. However, there is still a significant number of BCS intervened patients who are unpleasant with the result of the treatment, which leads to self-image issues and emotional overloads. Surgeons recognize the value of a tool to predict the breast shape after BCS to facilitate surgeon/patient communication and allow more educated decisions; however, no such tool is available that is suited for clinical usage. These tools could serve as a way of visually sensing the aesthetic consequences of the treatment. In this research, it is intended to propose a methodology for predict the deformation after BCS by using machine learning techniques. Nonetheless, there is no appropriate dataset containing breast data before and after surgery in order to train a learning model. Therefore, an in-house semi-synthetic dataset is proposed to fulfill the requirement of this research. Using the proposed dataset, several learning methodologies were investigated, and promising outcomes are obtained.

Abstract