Abstract
Capsule endoscopy is becoming the major medical technique for the examination of the gastrointestinal tract, and the detection of small bowel lesions. With the growth of endoscopic capsules and the lack of an appropriate tracking system to allow the localization of lesions, the need to develop software-based techniques for the localisation of the capsule at any given frame is also increasing. With this in mind, and knowing the lack of availability of labelled endoscopic datasets, this work aims to develop a unsupervised method for homography estimation in video capsule endoscopy frames, to later be applied in capsule localisation systems. The pipeline is based on an unsupervised convolutional neural network, with a VGG Net architecture, that estimates the homography between two images. The overall error, using a synthetic dataset, was evaluated through the mean average corner error, which was 34 pixels, showing great promise for the real-life application of this technique, although there is still room for the improvement of its performance. (C) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Peer-review under responsibility of the scientific committee of the CENTERIS -International Conference on ENTERprise Information Systems / ProjMAN - International Conference on Project MANagement / HCist - International Conference on Health and Social Care Information Systems and Technologies.

Abstract
Advances in genomics have driven to the recognition that tumours are populated by different minor subclones of malignant cells that control the way the tumour progresses. However, the spatial and temporal genomic heterogeneity of tumours has been a hurdle in clinical oncology. This is mainly because the standard methodology for genomic analysis is the biopsy, that besides being an invasive technique, it does not capture the entire tumour spatial state in a single exam. Radiographic medical imaging opens new opportunities for genomic analysis by providing full state visualisation of a tumour at a macroscopic level, in a non-invasive way. Having in mind that mutational testing of EGFR and KRAS is a routine in lung cancer treatment, it was studied whether clinical and imaging data are valuable for predicting EGFR and KRAS mutations in a cohort of NSCLC patients. A reliable predictive model was found for EGFR (AUC = 0.96) using both a Multi-layer Perceptron model and a Random Forest model but not for KRAS (AUC = 0.56). A feature importance analysis using Random Forest reported that the presence of emphysema and lung parenchymal features have the highest correlation with EGFR mutation status. This study opens new opportunities for radiogenomics on predicting molecular properties in a more readily available and non-invasive way. © 2019, Springer Nature Switzerland AG.

Abstract
Endoscopic capsules are vitamin-sized devices that leverage from a small wireless camera to create 8 to 10 hour videos of the patients' entire digestive tract, still being the leading tool to diagnose small bowel diseases. The revision of the produced videos is a very time-consuming task, currently conducted manually and frame-by-frame by an expert. Since endoscopic videos usually contain a considerable amount of frames where the mucosa is not clearly visible, the segmentation of the informative regions is a vital component to reduce the necessary time to review each exam. In this work, a CNN encoder-decoder architecture is applied to segment informative regions in small bowel frames of videos of endoscopic capsules. The network was trained and tested with a dataset of 2,929 manually annotated images, achieving a 91.2% Dice coefficient and 83.9% IoU. Furthermore, a video-wise analysis based on the amount of informative pixels in each frame is done.

Abstract
Wireless capsule endoscopy is a relatively novel technique used for imaging of the gastrointestinal tract. Unlike traditional approaches, it allows painless visualisation of the whole of the gastrointestinal tract, including the small bowel, a region of difficult access. Endoscopic capsules record for about 8h, producing around 60,000 images. These are analysed by an expert that identifies abnormalities present in the frames, a process that is very tedious and prone to errors. Thus there is a clear need to develop systems that automatically analyse this data and detect lesions. Lesion detection achieved a precision of 0.94 and a recall of 0.93 by fmetuning the pre-trained DenseNet-161 model. (C) 2019 The Authors. Published by Elsevier B.V.

Abstract
The deep inferior epigastric perforator (DIEP) is the most commonly used free flap in mastectomy reconstruction. Preoperative imaging techniques are routinely used to detect location, diameter and course of perforators, with direct intervention from the imaging team, who subsequently draw a chart that will help surgeons choosing the best vascular support for the reconstruction. In this work, the feasibility of using a computer software to support the preoperative planning of 40 patients proposed for breast reconstruction with a DIEP flap is evaluated for the first time. Blood vessel centreline extraction and local characterization algorithms are applied to identify perforators and compared with the manual mapping, aiming to reduce the time spent by the imaging team, as well as the inherent subjectivity to the task. Comparing with the measures taken during surgery, the software calibre estimates were worse for vessels smaller than 1.5 mm (P = 6e-4) but better for the remaining ones (P = 2e-3). Regarding vessel location, the vertical component of the software output was significantly different from the manual measure (P = 0.02), nonetheless that was irrelevant during surgery as errors in the order of 2-3 mm do not have impact in the dissection step. Our trials support that a reduction of the time spent is achievable using the automatic tool (about 2 h/case). The introduction of artificial intelligence in clinical practice intends to simplify the work of health professionals and to provide better outcomes to patients. This pilot study paves the way for a success story. (C) 2020 The Authors. Published by Elsevier Ltd.

Abstract
EGFR and KRAS are the most frequently mutated genes in lung cancer, being active research topics in targeted therapy. The biopsy is the traditional method to genetically characterise a tumour. However, it is a risky procedure, painful for the patient, and, occasionally, the tumour might be inaccessible. This work aims to study and debate the nature of the relationships between imaging phenotypes and lung cancer-related mutation status. Until now, the literature has failed to point to new research directions, mainly consisting of results-oriented works in a field where there is still not enough available data to train clinically viable models. We intend to open a discussion about critical points and to present new possibilities for future radiogenomics studies. We conducted high-dimensional data visualisation and developed classifiers, which allowed us to analyse the results for EGFR and KRAS biological markers according to different combinations of input features. We show that EGFR mutation status might be correlated to CT scans imaging phenotypes; however, the same does not seem to hold for KRAS mutation status. Also, the experiments suggest that the best way to approach this problem is by combining nodule-related features with features from other lung structures.