Abstract
Background/Objectives: Type 2 diabetes mellitus (T2DM) is a chronic condition marked by hyperglycemia, which can affect metabolic, vascular, and hematological parameters. A low-carbohydrate, high-fat (LCHF) diet has been shown to improve glycemic control and blood pressure regulation. Exercise in hypoxia (EH) enhances insulin sensitivity, erythropoiesis, and angiogenesis. The combination of LCHF and EH may offer a promising strategy for managing T2DM and hypertension (HTN), although evidence remains limited. This study aimed to assess the effects of an eight-week normobaric EH intervention at 3000 m simulated altitude combined with an LCHF diet on hematological and lipid profiles, inflammation, and blood pressure in older patients with T2DM and HTN. Methods: Forty-two diabetic patients with HTN were randomly assigned to three groups: (1) control group (control diet + exercise in normoxia), (2) EH group (control diet + EH), and (3) intervention group (EH+LCHF) Baseline and eight-week measurements included systolic, diastolic, and mean blood pressure (SBP, DBP, MAP), hematological and lipid profiles, and inflammation biomarkers. Results: Blood pressure decreased after the intervention (p < 0.001), with no significant differences between groups (SBP: p = 0.151; DBP: p = 0.124; MAP: p = 0.18). No differences were observed in lipid profile or C-reactive protein levels (p > 0.05). Mean corpuscular hemoglobin (MCH) increased in the EH group (p = 0.027), while it decreased in the EH+LCHF group (p = 0.046). Conclusions: Adding hypoxia or restricting carbohydrates did not provide additional benefits on blood pressure in T2DM patients with HTN. Further elucidation of the mechanisms underlying hematological adaptations is imperative.

Abstract
The large gap between the generalization level of state-of-the-art machine learning and human learning systems calls for the development of artificial intelligence (AI) models that are truly inspired by human cognition. In tasks related to image analysis, searching for pixel-level regularities has reached a power of information extraction still far from what humans capture with image-based observations. This leads to poor generalization when even small shifts occur at the level of the observations. We explore a perspective on this problem that is directed to learning the generative process with causality-related foundations, using models capable of combining symbolic manipulation, probabilistic reasoning, and pattern recognition abilities. We briefly review and explore connections of research from machine learning, cognitive science, and related fields of human behavior to support our perspective for the direction to more robust and human-like artificial learning systems.

Abstract
When each patient of a kidney exchange program has a preference ranking over its set of compatible donors, questions naturally arise surrounding the stability of the proposed exchanges. We extend recent work on stable exchanges by introducing and underlining the relevance of a new concept of locally stable, or L-stable, exchanges. We show that locally stable exchanges in a compatibility digraph are exactly the so-called local kernels (L-kernels) of an associated blocking digraph (whereas the stable exchanges are the kernels of the blocking digraph), and we prove that finding a nonempty L-kernel in an arbitrary digraph is NP-complete. Based on these insights, we propose several integer programming formulations for computing an L-stable exchange of maximum size. We conduct numerical experiments to assess the quality of our formulations and to compare the size of maximum L-stable exchanges with the size of maximum stable exchanges. It turns out that nonempty L-stable exchanges frequently exist in digraphs which do not have any stable exchange. All the above results and observations carry over when the concept of (locally) stable exchanges is extended to the concept of (locally) strongly stable exchanges.

Abstract
This work proposes an innovative methodology for the optimal placement of grid-forming converters (GFM) in converter-dominated grids while accounting for multiple stability classes. A heuristic-based methodology is proposed to solve an optimisation problem whose objective function encompasses up to 4 stability indices obtained through the simulation of a shortlist of disturbances. The proposed methodology was employed in a modified version of the 39-bus test system, using DigSILENT Power Factory as the simulation engine. First, the GFM placement problem is solved individually for the different stability classes to highlight the underlying physical phenomena that explain the optimality of the solutions and evidence the need for a multi-class approach. Second, a multi-class approach that combines the different stability indices through linear scalarisation (weights), using the normalised distance of each index to its limit as a way to define its importance, is adopted. For all the proposed fitness function formulations, the method successfully converged to a balanced solution among the various stability classes, thereby enhancing overall system stability.

Abstract
Industry 4.0 promotes a paradigm shift in the orchestration, oversight, and optimization of value chains across product and service life cycles. For instance, leveraging large-scale data from sensors and devices, coupled with Machine Learning techniques can enhance decision-making and facilitate various improvements in industrial settings, including predictive maintenance. However, ensuring data quality remains a significant challenge. Malfunctions in sensors or external factors such as electromagnetic interference have the potential to compromise data accuracy, thereby undermining confidence in related systems. Neglecting data quality not only compromises system outputs but also contributes to the proliferation of bad data, such as data duplication, inconsistencies, or inaccuracies. To consider these problems is crucial to fully explore the potential of data in Industry 4.0. This paper introduces an extensible system designed to ingest, organize, and monitor data generated by various sources, focusing on industrial settings. This system can serve as a foundation for enhancing intelligent processes and optimizing operations in smart manufacturing environments. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

Abstract
Influential nodes are the important nodes that most efficiently control the propagation process throughout the network. Among various structural-based methods, degree centrality, k-shell decomposition, or their combination identify influential nodes with relatively low computational complexity, making them suitable for large-scale network analysis. However, these methods do not necessarily explore nodes' underlying structure and neighboring information, which poses a significant challenge for researchers in developing timely and efficient heuristics considering appropriate network characteristics. In this study, we propose a new method (IC-SNI) to measure the influential capability of the nodes. IC-SNI minimizes the loopholes of the local and global centrality and calculates the topological positional structure by considering the local and global contribution of the neighbors. Exploring the path structural information, we introduce two new measurements (connectivity strength and effective distance) to capture the structural properties among the neighboring nodes. Finally, the influential capability of a node is calculated by aggregating the structural and neighboring information of up to two-hop neighboring nodes. Evaluated on nine benchmark datasets, IC-SNI demonstrates superior performance with the highest average ranking correlation of 0.813 with the SIR simulator and a 34.1% improvement comparing state-of-the-art methods in identifying influential spreaders. The results show that IC-SNI efficiently identifies the influential spreaders in diverse real networks by accurately integrating structural and neighboring information.