Abstract
The growing integration of renewable energy sources and the widespread electrification of the energy demand have significantly reduced the capacity margin of the electrical grid. This demands a more flexible approach to grid operation, for instance, combining real-time topology optimization and redispatching. Traditional expert-driven decision-making rules may become insufficient to manage the increasing complexity of real-time grid operations and derive remedial actions under the N-1 contingency. This work proposes a novel hybrid AI framework for power grid topology control that integrates genetic network programming (GNP), reinforcement learning, and decision trees. A new variant of GNP is introduced that is capable of evolving the decision-making rules by learning from data in a reinforcement learning framework. The graph-based evolutionary structure of GNP and decision trees enables transparent, traceable reasoning. The proposed method outperforms both a baseline expert system and a state-of-the-art deep reinforcement learning agent on the IEEE 118-bus system, achieving up to an 28% improvement in a key performance metric used in the Learning to Run a Power Network (L2RPN) competition.

Abstract
Eye diseases can have highly adverse outcomes without an early diagnosis and correct monitoring. Retinopathy of Prematurity (ROP) Plus Form, in particular, is a disease that can lead to childhood blindness, and its diagnosis requires medical experts to examine the retinal condition manually. Although developments in screening equipment have helped, this is still a time-consuming and subjective task. The development of automatic tools for Retinal Blood Vessel Segmentation allows the extraction of blood vessels from fundus images, which healthcare experts can then use to perform the diagnosis, monitoring, and prognosis of eye diseases. Thus, developing such a segmentation tool is a widely explored task with different methodologies that can be followed. However, many studies try to segment all the blood vessels rather than only the most important ones. In this work, we present a segmentation pipeline to segment only the main vessels whose characteristics can be used to assess ROP Plus Form disease. This pipeline uses different operations and filters, including CIELAB Enhancement, Background Normalization, Bell-Shaped Gaussian Matched Filtering, Modified Top-Hat operation, and Frangi Filtering. The final segmentation is done by determining a threshold value using the Triangle Threshold algorithm. The pipeline was tested in the well-known DRIVE Database, achieving an Accuracy of 0.949, Specificity of 0.963, and Sensitivity of 0.756. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2026.

Abstract
A novel technique based on multiple amplitude wavelength modulation spectroscopy (MA-WMS) for simultaneous measurement of CH4\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {CH}_4$$\end{document} gas concentration and pressure was developed and validated both through simulation and experiment, showing good agreement. To capture the spectrum broadening caused by increasing pressure and concomitantly obtain the concentration at the sensor's location, a laser centered at 1650.9 nm was subjected to multiple amplitude modulation depths while the 2fm\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$2f_{m}$$\end{document} signal, normalized by the DC component (an invariant quantity under optical loss), was recorded. While the use of a single and fixed modulation can introduce an ambiguity, as different pairs of pressure and concentration can yield the same value, this ambiguity is eliminated by employing multiple amplitude modulations. In this approach, the intersection point of the three level curves can provide the local pressure and concentration. The proposed system was able to measure concentrations from 5% up to 45% and pressures from 0.25 atm up to 1.75 atm, with a maximum error of 2% in concentration and 0.06 atm in pressure, respectively. The system was also tested for attenuation insensitivity, demonstrating that measurements were not significantly affected for up to 10 dB applied optical loss.

Abstract
This chapter provides an overview of the development Phases involved in transforming a technology originated in research into a medical product for commercialization. It first describes the four main Phases, from the emergence of the need for the product to its post-marketing obligations. It is intended to help the interested reader understand the stages, documents, guidelines, and regulations that a medical device must go through in order to be marketed. Special highlight is given to the necessary topics that must be addressed in order for the device to be certified. Every product that goes to market must be certified by some regulatory body in order to ensure that it will not cause any negative impact on its users. Further, for medical devices, these requirements are heightened, as they may come in contact with the user, potentially causing a direct risk to them. Thus, reading this chapter will provide the reader with an understanding of these Phases within the industrial environment as well as the aspects that must be taken into account before placing a medical device on the market. © Springer Nature Switzerland AG 2026.

Abstract

Abstract
This paper focuses on the comprehensive assessment of regional performance in attaining the 2030 Strategic Framework for Education and Training (ET2030) established by the European Union. To this end, we propose a composite indicator framework based on robust Benefit-of-the-doubt models empirically validated through an extensive analysis of data spanning 32 countries and 101 NUTS-I level regions for 2019. We integrate contextual variables into a robust conditional model to ensure an equitable evaluation among regions grappling with distinct circumstances. Specifically, the unemployment rate and the percentage of the population holding national citizenship are considered. Moreover, the research identifies best practices from high-performing regions that can serve as benchmarks for underperforming areas. Analyzing regional-level data is crucial for understanding disparities between European regions and within countries.