Abstract
Predicting and controlling crowd dynamics in emergencies is one of the main objectives of simulated emergency exercises. However, during emergency exercises, there is often a lack of sense of danger by the actors involved and concerns about exposing real people to potentially dangerous environments. These problems impose limitations in running an emergency drill, harming the collection of valuable information for posterior analysis and decision-making. This work aims to mitigate these problems by using Agent Based Modelling (ABM) simulator to deepen the comprehension of human actions when exposed to a sudden variation in extensive crowded environmental conditions and how evacuation strategies affect evacuation performance. To assess the impact of the evacuation strategy employed, we propose a modified informed leader-flowing approach and compare it with common evacuation strategies in a simulated environment, replicating stadium benches with narrow corridors leading to different exit points. The objective is to determine the impact of each set of configurations and evacuation strategies and compare them against other established ones. Our experiments determined that agents following the crowd generally lead to a higher number of victims due to the rise of herding phenomena near the exits, which was significantly reduced when agents were guided towards the exit via knowing the exit beforehand or following leader agent with real-time information regarding exit location and exit current state, proving that relevant and controlled information in combination with Follow Leader strategies can be crucial in an emergency evacuation scenario with limited evacuation exit capabi and distribution. © The Author(s) 2024.

Abstract
This paper explores advancements in Video Anomaly Detection (VAD), combining theoretical insights with practical solutions to address model limitations. Through comprehensive experimental analysis, the study examines the role of feature representations, sampling strategies, and curriculum learning in enhancing VAD performance. Key findings include the impact of class imbalance on the Cross-Modal Awareness-Local Arousal (CMALA) architecture and the effectiveness of techniques like pseudo-curriculum learning in mitigating noisy classes, such as Car Accident. Novel strategies like the Sample-Batch Selection (SBS) dynamic segment selection and pre-trained image-text models, including Contrastive Language-Image Pre-training (CLIP) and ViTamin encoder, significantly improve anomaly detection. The research underscores the potential of multimodal VAD, highlighting the integration of audio and visual modalities and the development of multimodal fusion techniques. To support this evolution, the study proposes a Unified WorkStation 4 VAD (UWS4VAD) to streamline research workflows and introduces a new VAD benchmark incorporating multimodal data and textual information. The work envisions enhanced anomaly interpretation and performance by leveraging joint representation learning and Large Language Models (LLMs). The findings set the stage for future advancements, advocating for large-scale pre-training on audio-visual datasets and shifting toward a more integrated, multimodal approach to VADs. Source code of the project available at https://github.com/zuble/uws4vad

Abstract
Clinical diagnosis of syndromes benefits strongly from objective facial phenotyping. This study introduces a novel approach to enhance clinical diagnosis through the development and exploration of a low-dimensional metric space referred to as the clinical face phenotypic space (CFPS). As a facial matching tool for clinical genetics, such CFPS can enhance clinical diagnosis. It helps to interpret facial dysmorphisms of a subject by placing them within the space of known dysmorphisms. In this paper, a triplet loss-based autoencoder developed by geometric deep learning (GDL) is trained using multi-task learning, which combines supervised and unsupervised learning approaches. Experiments are designed to illustrate the following properties of CFPSs that can aid clinicians in narrowing down their search space: a CFPS can 1) classify syndromes accurately, 2) generalize to novel syndromes, and 3) preserve the relatedness of genetic diseases, meaning that clusters of phenotypically similar disorders reflect functional relationships between genes. The proposed model consists of three main components: an encoder based on GDL optimizing distances between groups of individuals in the CFPS, a decoder enhancing classification by reconstructing faces, and a singular value decomposition layer maintaining orthogonality and optimal variance distribution across dimensions. This allows for the selection of an optimal number of CFPS dimensions as well as improving the classification capacity of the CFPS, which outperforms the linear metric learning baseline in both syndrome classification and generalization to novel syndromes. We further proved the usefulness of each component of the proposed framework, highlighting their individual impact. From a clinical perspective, the unique combination of these properties in a single CFPS results in a powerful tool that can be incorporated into current clinical practices to assess facial dysmorphism.

Abstract

Abstract
Obstructive sleep apnea is a heterogeneous sleep disorder with varying phenotypes. Several studies have already performed cluster analyses to discover various obstructive sleep apnea phenotypic clusters. However, the selection of the clustering method might affect the outputs. Consequently, it is unclear whether similar obstructive sleep apnea clusters can be reproduced using different clustering methods. In this study, we applied four well-known clustering methods: Agglomerative Hierarchical Clustering; K-means; Fuzzy C-means; and Gaussian Mixture Model to a population of 865 suspected obstructive sleep apnea patients. By creating five clusters with each method, we examined the effect of clustering methods on forming obstructive sleep apnea clusters and the differences in their physiological characteristics. We utilized a visualization technique to indicate the cluster formations, Cohen's kappa statistics to find the similarity and agreement between clustering methods, and performance evaluation to compare the clustering performance. As a result, two out of five clusters were distinctly different with all four methods, while three other clusters exhibited overlapping features across all methods. In terms of agreement, Fuzzy C-means and K-means had the strongest (kappa = 0.87), and Agglomerative hierarchical clustering and Gaussian Mixture Model had the weakest agreement (kappa = 0.51) between each other. The K-means showed the best clustering performance, followed by the Fuzzy C-means in most evaluation criteria. Moreover, Fuzzy C-means showed the greatest potential in handling overlapping clusters compared with other methods. In conclusion, we revealed a direct impact of clustering method selection on the formation and physiological characteristics of obstructive sleep apnea clusters. In addition, we highlighted the capability of soft clustering methods, particularly Fuzzy C-means, in the application of obstructive sleep apnea phenotyping.

Abstract

Good sleep is crucial for human life. Research has shown that poor-quality sleep is related to several cardiovascular and metabolic disorders. Sleep disorders are well categorized, and most of them have defined diagnostic criteria, with level 1 polysomnography being the gold standard. With the increasing use of technology, specifically smartphones, in people’s everyday lives, the search for alternative ways of monitoring sleep disorders or certain sleep parameters has been gaining relevance.