Abstract
Bipolar Disorder (BD) is a chronic and severe psychiatric illness presenting with mood alterations, including manic, hypomanic, and depressive episodes. Due to the high clinical heterogeneity and lack of biological validation, both treatment and diagnosis of BD remain problematic and challenging. In this context, this paper proposes a novel intelligent system applied to the diagnosis of BD. First, each patient’s single nucleotide polymorphism (SNP) data is represented by QR codes, which reduces the high dimensionality of the problem and homogenizes the data representation. For the initial tests of the system, the Wellcome Trust Case Control Consortium (WTCCC) dataset was used. The preliminary results are encouraging, with an AUC value of 0.82 and an accuracy of 82%, correctly classifying all cases and most controls. This approach reduces the dimensionality of large amounts of data and can help improve diagnosis and deliver the right treatment to the patient. Furthermore, the architecture of the system is versatile and could be adapted and used to diagnose other diseases where there is also high dimensionality. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

Abstract

Abstract
Motifs are overrepresented and statistically significant sub-patterns in a network, whose identification is relevant to uncover its underlying functional units. Recently, its extraction has been performed on higher-order networks, but due to the complexity arising from polyadic interactions, and the similarity with known computationally hard problems, its practical application is limited. Our main contribution is a novel approach for hyper-subgraph census and higher-order motif discovery, allowing for motifs with sizes 3 or 4 to be found efficiently, in real-world scenarios. It is consistently an order of magnitude faster than a baseline state-of-art method, while using less memory and supporting a wider range of base algorithms.

Abstract

Abstract
This paper introduces GERF, a Gamified Educational Virtual Escape Room Framework designed to enhance micro-learning and adaptive learning experiences in educational settings. The framework incorporates a user taxonomy based on the user type hexad, addressing the preferences and motivations of different learners profiles. GERF focuses on two key facets: interoperability and analytics. To ensure seamless integration of Escape Room (ER) platforms with Learning Management Systems (LMS), the Learning Tools Interoperability (LTI) specification is used. This enables smooth and efficient communication between ERs and LMS platforms. Additionally, GERF uses the xAPI specification to capture and transmit experiential data in the form of xAPI statements, which are then sent to a Learning Record Store (LRS). By leveraging these learning analytics, educators gain valuable insights into students’ interactions within the ER, facilitating the adaptation of learning content based on individual learning needs. Ultimately, GERF empowers educators to create personalized learning experiences within the ER environment, fostering student engagement and learning outcomes. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Abstract
This paper explores the integration of virtual escape rooms as innovative educational tools in the realm of computer programming. Recognizing the need to engage and motivate learners in this complex domain, we investigate the use of virtual escape rooms in a typical educational setting where Learning Management Systems play a pivotal role. The paper starts by surveying existing escape rooms designed for teaching programming and related domains, considering factors such as interactivity, educational efficacy, and learner engagement. Additionally, it is emphasized the role of standards in creating interoperable learning environments, introducing IMS LTI for seamless integration with learning management systems and xAPI for tracking learner activities within escape rooms. By leveraging these standards and a Learning Record Store (LRS) as a central repository, an architectural framework is presented which enables personalized learning experiences and data-driven insights, catering to the diverse needs and preferences of the new generation of learners.