Abstract
Two different sensing structures based on a hollow microsphere Fabry-Perot cavity are proposed. The hollow spheroidal cavities are fabricated resorting only to fusion splicing. The first structure is based on a hollow microsphere located at the fiber end and works as a probe sensor. The structure was subjected to lateral load pressure and presents a sensitivity of 1.56 +/- 0.01 nm/N. The second proposed sensor relies on an in-line hollow microsphere. The sensing structure allows the detection of lateral loading, with a sensitivity of 2.62 +/- 0.02 nm/N, as well as strain detection, with a sensitivity of 4.66 +/- 0.03 pm/mu epsilon. The two proposed sensors present similar response when subjected to temperature and have low thermal sensitivity.

Abstract
A Fabry-Perot air bubble microcavity fabricated between a section of single mode fiber and a multimode fiber is proposed. The study of the microcavities growth with the number of applied arcs is performed. The sensors are tested for lateral load and strain, where sensitivities of 0.32 nm/N and 2.11 nm/N and of 4.49 pm/mu epsilon and 9.12 pm/mu epsilon are obtained for the 47 mu m and 161 mu m long cavities, respectively. The way of manufacturing using a standard fusion splicer and given that no oils or etching solutions are involved, emerges as an alternative to the previously developed air bubble based sensors.

Abstract
The detection of dissolved carbon dioxide (dCO(2)) is made possible through a colorimetric effect that occurs in a sensitive membrane. The reaction with dCO(2) changes the pH of the membrane causing a small difference in its colour which results in a characteristic absorbance spectrum band near 435 nm. A sensing platform based on this effect was developed and tested in gaseous and in aqueous environments. It is a combination of a bundle of large core fibre optics (with diameters above 200 mu m) with light emission diodes (LEDs) in the visible range of the spectrum, a silicon photodetector and a polymer membrane sensitive to CO2. A variation in the absorption of 3 / %VV was obtained in the range from 0 to 1.6 % of gaseous CO2 with an estimated response time below 60 seconds.

Abstract
A Fabry-Perot air bubble microcavity fabricated between a section of single mode fiber and a multimode fiber that requires only the use of a commercial fusion splicer is proposed. The study of the microcavities growth with the number of applied arcs is performed and several sensors are tested. The sensors are tested for lateral load measurements, and it is observed that there is dependence between the sensor dimensions and its sensitivity. The maximum sensitivity of 2.11 nm/N was obtained for the 161-mu m-long cavity. Moreover, given the low temperature sensitivity (<1 pm/degrees C), the proposed cavity should be adequate to perform temperature-independent measurements. The accurate technique control leads to the fabrication of reproducible cavities with the sensitivity required for the application. The way of manufacturing using a standard fusion splicer, given that no oils or etching solutions are involved, emerges as an alternative to the previously developed air bubble-based sensors.

Abstract
The detection of thrombin based on aptamer binding is studied using two different optical fiber-based configurations: long period gratings coated with a thin layer of titanium dioxide and surface plasmon resonance devices in optical fibers coated with a multilayer of gold and titanium dioxide. These structures are functionalized and the performance to detect thrombin in the range 10 to 100 nM is compared in transmission mode. The sensitivity to the surrounding refractive index (RI) of the plasmonic device is higher than 3100 nmRIU(-1) in the RI range 1.335 to 1.355, a factor of 20 greater than the sensitivity of the coated grating. The detection of 10 nM of thrombin was accomplished with a wavelength shift of 3.5 nm and a resolution of 0.54 nM. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)

Abstract
A label-free fiber optic biosensor based on a long period grating (LPG) and a basic optical interrogation scheme using off the shelf components is used for the detection of in-situ DNA hybridization. A new methodology is proposed for the determination of the spectral position of the LPG mode resonance. The experimental limit of detection obtained for the DNA was 62 +/- 2 nM and the limit of quantification was 209 +/- 7 nM. The sample specificity was experimentally demonstrated using DNA targets with different base mismatches relatively to the probe and was found that the system has a single base mismatch selectivity.