Abstract
In addition to evaluating tumor morphology using H&E staining, immunohistochemistry is used to assess the presence of specific proteins within the tissue. However, this is a costly and labor-intensive technique, for which virtual staining, as an image-to-image translation task, offers a promising alternative. Although recent, this is an emerging field of research with 64% of published studies just in 2024. Most studies use publicly available datasets of H&E-IHC pairs from consecutive tissue sections. Recognizing the training challenges, many authors develop complex virtual staining models based on conditional Generative Adversarial Networks but ignore the impact of adversarial loss on the quality of virtual staining. Furthermore, overlooking the issues of model evaluation, they claim improved performance based on metrics such as SSIM and PSNR, which are not sufficiently robust to evaluate the quality of virtually stained images. In this paper, we developed CSSP2P GAN, which we demonstrate to achieve heightened pathological fidelity through a blind pathological expert evaluation. Furthermore, while iteratively developing our model, we study the impact of the adversarial loss and demonstrate its crucial role in the quality of virtually stained images. Finally, while comparing our model with reference works in the field, we underscore the limitations of the currently used evaluation metrics and demonstrate the superior performance of CSSP2P GAN.

Abstract
This work reflects upon what Immersion can mean from the perspective of an Artificial Intelligence (AI). Applying the lens of immersive learning theory, it seeks to understand whether this new perspective supports ways for AI participation in cognitive ecologies. By treating AI as a participant rather than a tool, it explores what other participants (humans and other AIs) need to consider in environments where AI can meaningfully engage and contribute to the cognitive ecology, and what the implications are for designing such learning environments. Drawing from the three conceptual dimensions of immersion-System, Narrative, and Agency-this work reinterprets AIs in immersive learning contexts. It outlines practical implications for designing learning environments where AIs are surrounded by external digital services, can interpret a narrative of origins, changes, and structural developments in data, and dynamically respond, making operational and tactical decisions that shape human-AI collaboration. Finally, this work suggests how these insights might influence the future of AI training, proposing that immersive learning theory can inform the development of AIs capable of evolving beyond static models. This paper paves the way for understanding AI as an immersive learner and participant in evolving human-AI cognitive ecosystems.

Abstract

Abstract

Abstract
3D models are crucial in predicting aesthetic outcomes in breast reconstruction, supporting personalized surgical planning, and improving patient communication. In response to this necessity, this is the first application of Radiance Fields to 3D breast reconstruction. Building on this, the work compares six SoTA 3D reconstruction models. It introduces a novel variant tailored to medical contexts: Depth-Splatfacto, designed to improve denoising and geometric consistency through pseudo-depth supervision. Additionally, we extended model training to grayscale, which enhances robustness under grayscale-only input constraints. Experiments on a breast cancer patient dataset demonstrate that Splatfacto consistently outperforms others, delivering the highest reconstruction quality (PSNR 27.11, SSIM 0.942) and the fastest training times (x1.3 faster at 200k iterations). At the same time, the depth-enhanced variant offers an efficient and stable alternative with minimal fidelity loss. The grayscale train improves speed by x1.6 with a PSNR drop of 0.70. Depth-Splatfacto further improves robustness, reducing PSNR variance by 10% and making images less blurry across test cases. These results establish a foundation for future clinical applications, supporting personalized surgical planning and improved patient-doctor communication.

Abstract
Python has become one of the most widely used programming languages, yet the transition fromPython 2 to 3 introduced a tension between innovation and compatibility. While new featuressuch as formatted string literals, type annotations, and structural pattern matching expanded thelanguage’s expressiveness, they also required substantial adaptation of legacy code. Despite theincreasing relevance of these features, there is still limited empirical evidence on how modernPython features are being adopted in practice—when developers start using them, how adoptionunfolds over time, and what motivations drive these decisions. This paper addresses this gapthrough a large-scale empirical study of 424 open-source Python projects. Our analysis revealstwo distinct adoption patterns: rapid adoption of small syntactic improvements and slowerintegration of features that require extensive refactoring or ecosystem support. On average,projects begin using with new features within 16 months after their release but take roughly 4years to achieve broader and sustained adoption. This observation may be partially explainedby the transition from Python 2 to 3, which did not preserve full backward compatibility.Complementary qualitative evidence from pull-request discussions indicates that developers areprimarily motivated to rejuvenate Python code through improvements in comprehension, safety,and performance, yet often constrained by compatibility requirements and maintenance costs.Together, these findings offer practical insights for tool developers and maintainers seeking tobalance innovation and stability in the ongoing rejuvenation of Python source code.