Abstract
This paper reflects on review of smart sensor activities for biomedical applications. The rise of biotechnology has provided innovative development of new therapies and detection methods for life threatening diseases. As a worldwide research focus, there is especially a strong interest in the use of microsystems in health care, particularly as smart implantable devices. Recent years have seen an increasing activity of hip and knee replacement and other type of implants, which are some of the most frequently performed surgical procedures in the world. Loosening of hip prosthesis is the dominant issue for many patients who undergo a hip arthroplasty. Artificial joints are subject to chronic infections associated with bacterial biofilms, which only can be eradicated by the traumatic removal of the implant followed by sustained intravenous antibiotic therapy. This review focuses on the clinical experience using all kinds of smart implants like orthopedic implants instrumented with strain gauges, retina implant system using image sensors. Technical design improvements will enhance function, quality of life, and longevity of total knee arthroplasty and all other kind of implants. Application of biocompatible nanomaterials in implantable biosensors for continuous monitoring of metabolites is an area of sustained scientific and technological interests. Crown Copyright

Abstract
In this research programme, methodologies for structural health monitoring (SHM) of composite over-wrapped pressure vessels (COPV) were addressed. So, this work is part of the development of a COPV laboratorial prototype incorporated with non-destructive sensing technologies. The aim is to detect and identify critical aspects that can happen during operation, in order to reduce possible safety problems. Fibre Bragg grating (FBG) optical sensors and polyvinylidene fluoride (PVDF) polymeric piezoelectric were the selected sensing technologies. These sensors were embedded in the liner-composite interface during its manufacturing and monitored the prototype while tested under cyclic internal pressure loading. The measurements collected from the sensors were compiled with the analysis of test data and are presented in this paper. Also, the suitability of the two sensing technologies, issues related to sensor embedding and the monitoring strategy are discussed.

Abstract
The aim of this work was the study and understanding of the behavior and linearity of an optical fiber Bragg grating (FBG) sensor embedded in bone cement. Test its ability to monitor strains inside bone cement during different mechanical tests, at real-time. Bone cement is a biomaterials based on polymethacrylate used as fixation method in artificial joints. Work as a bonding, load transfer and optimal Stress/strain distribution inside the complex human body environment, Bone cement is the weakest element in a joint implant, being considered the main reason of prosthesis loosening. Inside the bone cement, its temperature, longitudinal strain and load were measured using fiber Bragg gratings. All the measurements report a linear response showing a good adaptation and optimization of the load transfer between the biomaterial and the embedded optical sensor.

Abstract
An interferometer based on a D-shape chaotic optical fiber for measurement of multiparameters was proposed. The sensing structure relied on a D-shape fiber section spliced in between two singlemode fibers and interrogated in transmission. The optical spectrum was composed by multiple interference loss peaks, which were sensitive to the refractive index, temperature and strain-maximum sensitivities of 95.2 nm/RIU, 10.5 pm/ and -3.51 pm/µe, respectively, could be achieved. © The Author(s) 2012.

Abstract
A temperature-insensitive strain sensor based on Four-Wave Mixing (FWM) using two Raman fiber Bragg grating (FBG) lasers with cooperative Rayleigh scattering is proposed. Two FBG were used to form two linear cavities laser sensors based on Raman amplification combined with cooperative Rayleigh scattering. Due to the very low dispersion coefficient of the fiber, it is possible to obtain the FWM using the two lasers. This configuration allows the operation as a temperature-insensitive strain sensor where both sensors have the same sensitivity to temperature but only one of the FBG laser is sensitive to strain. The difference between the wavelengths of the signal sensor and the converted signal presents a strain coefficient sensitivity of 2 pm/mu epsilon with insensitivity to temperature. The FWM efficiency is also dependent on the applied strain, but it is temperature independent, presenting a maximum sensibility of 0.01 dB/mu epsilon.

Abstract
It is described a large-core air-clad photonic crystal fiber-based sensing structure using the outer cladding as a light guide, which is highly sensitive to refractive index. The sensing head is based on multimodal interference, and relies on a single mode/large-core air-clad photonic crystal fiber/single mode fiber configuration. Using this configuration and controlling the light to travel in a segment of the outer cladding multimode fiber, it was possible to implement a sensing head and the results were obtained independently from variations of temperature, strain and refractive index. (c) 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:10091011, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26726