Abstract
Background This scoping review systematically maps externally validated machine learning (ML)-based models in cancer patient care, quantifying their performance, and clinical utility, and examining relationships between models, cancer types, and clinical decisions. By synthesizing evidence, this study identifies, strengths, limitations, and areas requiring further research. Methods The review followed the Joanna Briggs Institute's methodology, Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines, and the Population, Concept, and Context mnemonic. Searches were conducted across Embase, IEEE Xplore, PubMed, Scopus, and Web of Science (January 2014-September 2022), targeting English-language quantitative studies in Q1 journals (SciMago Journal and Country Ranking > 1) that used ML to evaluate clinical outcomes for human cancer patients with commonly available data. Eligible models required external validation, clinical utility assessment, and performance metric reporting. Studies involving genetics, synthetic patients, plants, or animals were excluded. Results were presented in tabular, graphical, and descriptive form. Results From 4023 deduplicated abstracts and 636 full-text reviews, 56 studies (2018-2022) met the inclusion criteria, covering diverse cancer types and applications. Convolutional neural networks were most prevalent, demonstrating high performance, followed by gradient- and decision tree-based algorithms. Other algorithms, though underrepresented, showed promise. Lung and digestive system cancers were most frequently studied, focusing on diagnosis and outcome predictions. Most studies were retrospective and multi-institutional, primarily using image-based data, followed by text-based and hybrid approaches. Clinical utility assessments involved 499 clinicians and 12 tools, indicating improved clinician performance with AI assistance and superior performance to standard clinical systems. Discussion Interest in ML-based clinical decision-making has grown in recent years alongside increased multi-institutional collaboration. However, small sample sizes likely impacted data quality and generalizability. Persistent challenges include limited international validation across ethnicities, inconsistent data sharing, disparities in validation metrics, and insufficient calibration reporting, hindering model comparison reliability.

Abstract
Uncertainty is pervasive in modern manufacturing settings. In order to cope with unexpected events, scheduling decisions are commonly taken resorting to dispatching rules, which are reactive in nature. However, rule performance varies according to shop utilisation and due date allowance, which often change in dynamic real-world job shops. Therefore, this paper explores systems that select dispatching rules as conditions change over time, namely periodic and real-time dispatching rule selection systems, which are based on supervised learning and reinforcement learning algorithms, respectively. These types of systems have been proposed in the past but have been further improved in this work by carefully selecting the most relevant state features and dispatching rules. Moreover, by testing both approaches on the same instances, it was possible to compare them and determine the most advantageous one. After the tests, which included a wide array of job shop instances, both periodic and real-time systems outperformed state-of-the-art dispatching rules by over 10% tardiness-wise. Nonetheless, the periodic rule selection approach was more robust across all tests than the real-time approach. These results demonstrate that there is a real incentive for managers to adopt dispatching rule selection systems. © 2025 Elsevier B.V., All rights reserved.

Abstract
Retailers offering Attended Home Delivery (AHD) struggle with thin profit margins due to high delivery costs and constrained routing flexibility. AHD requires retailers and customers to agree on specific time windows, limiting operational efficiency and increasing fleet requirements, particularly when customer preferences tend to cluster around peak times. While retailers have some ability to influence customer choices through pricing and availability strategies, failing to account for fleet costs and delivery constraints can lead to inefficient operations and reduced profitability. This study introduces an integrated approach to fleet sizing and time-window pricing for price-sensitive customers. We propose a Mixed Integer Programming (MIP) model that maximizes profit by balancing revenue and delivery costs, leveraging a nonparametric rank-based choice model to capture customer behavior while explicitly considering routing constraints and fleet ownership expenses over multiple periods. Using computational experiments on small-sized instances inspired by real-world data, we evaluate the impact of explicitly modeling routing costs, compare different pricing strategies, examine the effects of multi-period fleet planning, and assess sensitivity to varying customer and cost conditions. Results show that explicitly modeling routing constraints reduces profit loss by 29% compared to traditional cost approximations but increases computational complexity. To address this, we develop a Fix & Optimize (F&O) matheuristic approximate solution method that enables the application of our model to larger instances. Our findings emphasize the need for retailers to integrate demand management and fleet planning to optimize operational profitability.

Abstract
This paper presents the development process of the mobile App D.R.E.A.M., Design-thinking to Reach-out, Embrace and Acknowledge Mental health, which is a tool for self-assessment and self-care in promoting the mental health of higher education students. In Portugal, the program for promoting Mental Health in higher education advocates the development and use of digital tools, such as apps and/or social networks and platforms, aimed at promoting wellbeing and with the potential for use to be more accessible to higher education students. The objective of this app is to promote the mental health and wellbeing of higher education students. Design Thinking was used as the methodology for building the app, which was developed using a combination of low-code/no-code tools, Flutter/Dart coding, and Google's Firebase capabilities and database functionalities. In the first semester of the 2023/2024 academic year, 484 students downloaded the app, and 22 emails were received for psychological consultations. A dynamic update of the app is required, with modules on time management and study organization, structured physical activity programs, development of socio-entrepreneurial skills, and vocational area.

Abstract
The extraction of phenolic compounds from eucalyptus leaves was optimized using heat and ultrasound-assisted techniques, and the bioactive potential of the resulting extract was assessed. The independent variables, including time (t), solvent concentration (S), and temperature (T) or power (P), were incorporated into a five- level central composite design combined with Response Surface Methodology. Phenolic content was determined by HPLC-DAD-ESI/MS and used as response criteria. The developed models were successfully fitted to the experimental data to identify the optimal extraction conditions. Heat-assisted extraction proved to be the most efficient method for phenolic recovery, yielding 27 +/- 2 mg/g extract under optimal conditions (120 min, 76.5 degrees C, and 25 % ethanol, v/v). The extracts exhibited a high concentration of phenolic glycoside derivatives, including gallotannin, quercetin, and isorhamnetin. These findings suggest that the extracts hold promise as natural additives in food technology, owing to their moderate antimicrobial activity and strong antioxidant properties.

Abstract
The energy policy of the European Union stresses the need for sustainable energy consumption, improvements in energy efficiency and lower fossil fuel dependence in a decoupling strategy from unstable democracies. Transportation still represents a sector largely dependent on fossil fuels, which come with several negative impacts. Measuring and assessing the sustainability of the transport sector becomes necessary. This study aims to assess the sustainability performance of the transport sector across 28 European countries over a four-year period, aligned with the policy agenda outlined in strategic documents. The methodological approach involves applying Benefit-of-the-Doubt (BoD) models, comparing aversion that uses transformation methods for anti- isotonic sub-indicators with a variant that directly incorporates these sub-indicators as reverse indicators. In general, the European countries have improved the sustainability performance of their transport sector during the time span analyzed according to the results of both models. For the inefficient units, two improvement strategies are presented based on the profiles identified on the benchmarks from both models, which can be alternative stages to achieve the robust best practices of the benchmarks.