Abstract
The direct calculation of the absorption coefficient spectra of various tissues from spectral measurements allowed to retrieve the contents of melanin and lipofuscin. In the rabbit brain cortex, 1.8 times higher melanin content is explained by the neuron degeneration process. Similar melanin and lipofuscin contents were found in the rabbit pancreas as a result of the tissue aging process. The conversion of 83 % of the melanin in the human normal kidney into lipofuscin in the cancer kidney indicates that lipofuscin can be considered a kidney cancer marker in humans. © 2022 IEEE.

Abstract
The increase of tissue transparency through sequential optical immersion clearing treatments and treatment reversibility have high interest for clinical applications. To evaluate the clearing reversibility in a broad spectral range and the magnitude of the transparency created by a second treatment, the present study consisted on measuring the spectral collimated transmittance of lung tissues during a sequence of two treatments with electronic cigarette (e-cig) fluid, which was intercalated with an immersion in saline. The saline immersion clearly reverted the clearing effect in the lung tissue in the spectral range between 220 and 1000 nm. By a later application of a second treatment with the e-cig fluid, the magnitude of the optical clearing effect was observed to be about the double as the one observed in the first treatment, showing that the molecules of the optical clearing agent might have converted some bound water into mobile water during the first treatment.

Abstract

Abstract

Abstract
Healthcare environments are generating a deluge of sensitive data. Nonetheless, dealing with large amounts of data is an expensive task, and current solutions resort to the cloud environment. Additionally, the intersection of the cloud environment and healthcare data opens new challenges regarding data privacy. With this in mind, we propose MEDCLOUDCARE (MCC), a healthcare application offering medical image viewing and processing tools while integrating cloud computing and AI. Moreover, MCC provides security and privacy features, scalability and high availability. The system is intended for two user groups: health professionals and researchers. The former can remotely view, process and share medical imaging information in the DICOM format. Also, it can use pre-trained Machine Learning (ML) models to aid the analysis of medical images. The latter can remotely add, share, and deploy ML models to perform inference on DICOM images. MCC incorporates a DICOM web viewer enabling users to view and process DICOM studies, which they can also upload and store. Regarding the security and privacy of the data, all sensitive information is encrypted at rest and in transit. Furthermore, MCC is intended for cloud environments. Thus, the system is deployed using Kubernetes, increasing the efficiency, availability and scalability of the ML inference process.

Abstract
The recent increasing interest in the application of radiology contrasting agents to create transparency in biological tissues implies that the diffusion properties of those agents need evaluation. The comparison of those properties with the ones obtained for other optical clearing agents allows to perform an optimized agent selection to create optimized transparency in clinical applications. In this study, the evaluation and comparison of the diffusion properties of gadobutrol and glycerol in skeletal muscle was made, showing that although gadobutrol has a higher molar mass than glycerol, its low viscosity allows for a faster diffusion in the muscle. The characterization of the tissue dehydration and refractive index matching mechanisms of optical clearing was made in skeletal muscle, namely by the estimation of the diffusion coefficients for water, glycerol and gadobutrol. The estimated tortuosity values of glycerol (2.2) and of gadobutrol (1.7) showed a longer path-length for glycerol in the muscle.