Abstract
In this manuscript a novel method is presented for left ventricle (LV) tracking in three-dimensional ultrasound data using a hybrid approach combining segmentation and tracking-based clues. This is accomplished by coupling an affine motion model to an existing LV segmentation framework and introducing an energy term that penalizes the deviation to the affine motion estimated using a global Lucas–Kanade algorithm. The hybrid nature of the proposed solution can be seen as using the estimated affine motion to enhance the temporal coherence of the segmented surfaces, by enforcing the tracking of consistent patterns, while the underlying segmentation algorithm allows to locally refine the estimated global motion. The proposed method was tested on a dataset composed of 24 4D ultrasound sequences from both healthy volunteers and diseased patients. The proposed hybrid tracking platform offers a competitive solution for fast assessment of relevant LV volumetric indices, by combining the robustness of affine motion tracking with the low computational burden of the underlying segmentation algorithm. © 2017 Elsevier Ltd

Abstract
Fast volumetric cardiac imaging requires reducing the number of transmit events within a single volume. One way of achieving this is by limiting the field of view (FOV) of the recording to the myocardium when investigating cardiac mechanics. Although fully automatic solutions towards myocardial segmentation exist, translating that information in a fast ultrasound scan sequence is not trivial. In particular, multi-line transmit (MLT) scan sequences were investigated given their proven capability to increase frame rate (FR) while preserving image quality. The aim of this study was therefore to develop a methodology to automatically identify the anatomically relevant conically shaped FOV, and to translate this to the best associated MLT sequence. This approach was tested on 27 datasets leading to a conical scan with a mean opening angle of 19.7° ± 8.5°, while the mean "thickness" of the cone was 19° ± 3.4°, resulting in a frame rate gain of about 2. Then, to subsequently scan this conical volume, several MLT setups were tested in silico. The method of choice was a 10MLT sequence as it resulted in the highest frame rate gain while maintaining an acceptable cross-talk level. When combining this MLT scan sequence with at least four parallel receive beams, a total frame rate gain with a factor of approximately 80 could be obtained. As such, anatomical scan sequences can increase frame rate significantly while maintaining information of the relevant structures for functional myocardial imaging. © 2017 by the authors.

Abstract
Background and Objectives: In spite of the existence of a multitude of techniques that allow the estimation of stress from physiological indexes, its fine-grained assessment is still a challenge for biomedical engineering. The short-term assessment of stress condition overcomes the limits to stress characterization with long blocks of time and allows to evaluate the behaviour change in real-world settings and also the stress level dynamics. The aim of the present study was to evaluate time and frequency domain and nonlinear heart rate variability (HRV) metrics for stress level assessment using a short-time window. Methods: The electrocardiogram (ECG) signal from 14 volunteers was monitored using the Vital Jacketml while they performed the Trier Social Stress Test (TSST) which is a standardized stress-inducing protocol. Window lengths from 220 s to 50 s for HRV analysis were tested in order to evaluate which metrics could be used to monitor stress levels in an almost continuous way. Results: A sub-set of HRV metrics (AVNN, rMSSD, SDNN and pNN20) showed consistent differences between stress and non-stress phases, and showed to be reliable parameters for the assessment of stress levels in short-term analysis. Conclusions: The AVNN metric, using 50 s of window length analysis, showed that it is the most reliable metric to recognize stress level across the four phases of TSST and allows a fine-grained analysis of stress effect as an index of psychological stress and provides an insight into the reaction of the autonomic nervous system to stress.

Abstract
Cardiac volume/function assessment remains a critical step in daily cardiology, and 3-D ultrasound plays an increasingly important role. Though development of automatic endocardial segmentation methods has received much attention, the same cannot be said about epicardial segmentation, in spite of the importance of full myocardial segmentation. In this paper, different ways of coupling the endocardial and epicardial segmentations are contrasted and compared with uncoupled segmentation. For this purpose, the B-spline explicit active surfaces framework was used; 27 3-D echocardiographic images were used to validate the different coupling strategies, which were compared with manual contouring of the endocardial and epicardial borders performed by an expert. It is shown that an independent segmentation of the endocardium followed by an epicardial segmentation coupled to the endocardium is the most advantageous. In this way, a framework for fully automatic 3-D myocardial segmentation is proposed using a novel coupling strategy.

Abstract
During social communication, words and sentences play a critical role in the expression of emotional meaning. The Minho Affective Sentences (MAS) were developed to respond to the lack of a standardized sentence battery with normative affective ratings: 192 neutral, positive, and negative declarative sentences were strictly controlled for psycholinguistic variables such as numbers of words and letters and per-million word frequency. The sentences were designed to represent examples of each of the five basic emotions (anger, sadness, disgust, fear, and happiness) and of neutral situations. These sentences were presented to 536 participants who rated the stimuli using both dimensional and categorical measures of emotions. Sex differences were also explored. Additionally, we probed how personality, empathy, and mood from a subset of 40 participants modulated the affective ratings. Our results confirmed that the MAS affective norms are valid measures to guide the selection of stimuli for experimental studies of emotion. The combination of dimensional and categorical ratings provided a more fine-grained characterization of the affective properties of the sentences. Moreover, the affective ratings of positive and negative sentences were not only modulated by participants' sex, but also by individual differences in empathy and mood state. Together, our results indicate that, in their quest to reveal the neurofunctional underpinnings of verbal emotional processing, researchers should consider not only the role of sex, but also of interindividual differences in empathy and mood states, in responses to the emotional meaning of sentences.

Abstract
This article presents an optimal estimator for discrete-time systems disturbed by output white noise, where the proposed algorithm identifies the parameters of a Multiple Input Single Output LPV State Space model. This is an LPV version of a class of algorithms proposed elsewhere for identifying LTI systems. These algorithms use the matchable observable linear identification parameterization that leads to an LTI predictor in a linear regression form, where the ouput prediction is a linear function of the unknown parameters. With a proper choice of the predictor parameters, the optimal prediction error estimator can be approximated. In a previous work, an LPV version of this method, that also used an LTI predictor, was proposed; this LTI predictor was in a linear regression form enablin, in this way, the model estimation to be handled by a Least-Squares Support Vector Machine approach, where the kernel functions had to be filtered by an LTI 2D-system with the predictor dynamics. As a result, it can never approximate an optimal LPV predictor which is essential for an optimal prediction error LPV estimator. In this work, both the unknown parameters and the state-matrix of the output predictor are described as a linear combination of a finite number of basis functions of the scheduling signal; the LPV predictor is derived and it is shown to be also in the regression form, allowing the unknown parameters to be estimated by a simple linear least squares method. Due to the LPV nature of the predictor, a proper choice of its parameters can lead to the formulation of an optimal prediction error LPV estimator. Simulated examples are used to assess the effectiveness of the algorithm. In future work, optimal prediction error estimators will be derived for more general disturbances and the LPV predictor will be used in the Least-Squares Support Vector Machine approach.