Abstract
Background and objectives: Timely treatment of pediatric obstructive sleep apnea (OSA) can prevent or reverse neurocognitive and cardiovascular morbidities. However, whether distinct phenotypes exist and account for divergent treatment effectiveness remains unknown. In this study, our goal is threefold: i) to define new data-driven pediatric OSA phenotypes, ii) to evaluate possible treatment effectiveness differences among them, and iii) to assess phenotypic information in predicting OSA resolution. Methods: We involved 22 sociodemographic, anthropometric, and clinical data from 464 children (5-10 years old) from the Childhood Adenotonsillectomy Trial (CHAT) database. Baseline information was used to automatically define pediatric OSA phenotypes using a new unsupervised subject-based association network. Follow-up data (7 months later) were used to evaluate the effects of the therapeutic intervention in terms of changes in the obstructive apnea-hypopnea index (OAHI) and the resolution of OSA (OAHI < 1 event per hour). An explainable artificial intelligence (XAI) approach was also developed to assess phenotypic information as OSA resolution predictor at baseline. Results: Our approach identified three OSA phenotypes (PHOSA1-PHOSA3), with PHOSA2 showing significantly lower odds of OSA recovery than PHOSA1 and PHOSA3 when treatment information was not considered (odds ratios, OR: 1.64 and 1.66, 95 % confidence intervals, CI: 1.03-2.62 and 1.01-2.69, respectively). The odds of OSA recovery were also significantly lower in PHOSA2 than in PHOSA3 when adenotonsillectomy was adopted as treatment (OR: 2.60, 95 % CI: 1.26-5.39). Our XAI approach identified 79.4 % (CI: 69.9-88.0 %) of children reaching OSA resolution after adenotonsillectomy, with a positive predictive value of 77.8 % (CI: 70.3 %-86.0 %). Conclusions: Our new subject-based association network successfully identified three clinically useful pediatric OSA phenotypes with different odds of therapeutic intervention effectiveness. Specifically, we found that children of any sex, >6 years old, overweight or obese, and with enlarged neck and waist circumference (PHOSA2) have less odds of recovering from OSA. Similarly, younger female children with no enlarged neck (PHOSA3) have higher odds of benefiting from adenotonsillectomy.

Abstract
Effective selection of forecasting algorithms for time series data is a challenge in machine learning, impacting both predictive accuracy and efficiency. Metalearning, using features extracted from time series, offers a strategic approach to optimize algorithm selection. The utility of this approach depends on the amount of information the features contain about the behavior of the algorithms. Although there are several methods for systematic time series feature extraction, they have never been compared. This paper empirically analyzes the performance of each feature extraction method for algorithm selection and its impact on forecasting accuracy. Our study reveals that TSFRESH, TSFEATURES, and TSFEL exhibit comparable performance at algorithm selection accuracy, adeptly capturing time series characteristics essential for accurate algorithm selection. In contrast, Catch22 is found to be less effective for this purpose. In particular, TSFEL is identified as the most efficient method, balancing dimensionality and predictive performance. These findings provide insights for enhancing forecasting accuracy and efficiency through judicious selection of meta-feature extractors.

Abstract
Predictive Maintenance (PdM) aims to prevent failures through early detection, yet lacks explainability to support decision-making. Current PdM models often identify failures, but fail to explain their root causes, especially in real-world scenarios, with complex and limited labeled data. This study proposes an interpretable framework that combines LSTM-based Anomaly Detection with a dual-layered Root Cause Analysis (RCA) based on SHAP attributions. Applied to a real-world dataset, the method detects degradation transitions, tracks failure patterns over time, and provides interpretable information without explicit root cause labels.

Abstract
Automated seizure quantification and classification are needed for semiology-based epileptic seizure diagnosis support. To the best of our knowledge, the 5-class (Hypermotor, Automotor, Complex Motor, Psychogenic Non-Epileptic Seizures, and Generalized Tonic-Clonic Seizures) seizure video dataset (198 seizures from 74 patients) studied in this paper is the largest 5-class dataset ever curated, composed of monocular RGB videos from two university hospital epilepsy monitoring units. 2D skeletons were estimated using ViTPose, a vision transformer deep learning (DL) architecture, and lifted to 3D space using MotionBERT, a multimodal motion transformer architecture. The movements were quantified based on the estimated 3D skeleton sequences. Two approaches were evaluated for seizure classification: (1) classical machine learning methods (Random Forest (RF) and XGBoost) applied to quantified movement parameters, and (2) 2D skeleton-based DL using MotionBERT action, an action recognition DL model, to which we perform transfer-learning. The best model achieved a promising, above literature, 5-fold cross-validated macro average F1-score of 0.84 +/- 0.09 (RF) for 5-class classification. The binary case (Automotor vs Hypermotor) resulted in 0.80 +/- 0.18 (MotionBERT action), and adding a 3rd class (Complex motor) lowered to 0.65 +/- 0.14 (RF). This novel multi-stage classification ensures that the included movement features are traceable, allowing interpretable AI exploration of this novel approach supporting future clinical diagnosis.

Abstract
Federated Learning (FL) enables decentralized model training while preserving data privacy but remains susceptible to poisoning attacks. Malicious clients can manipulate local data or model updates, threatening FL's reliability, especially in privacy-sensitive domains like healthcare and finance. While client-side optimization algorithms play a crucial role in training local models, their resilience to such attacks is underexplored. This study empirically evaluates the robustness of three widely used optimization algorithms: SGD, Adam, and RMSProp-against label-flipping attacks (LFAs) in image classification tasks using Convolutional Neural Networks (CNNs). Through 900 individual runs in both federated and centralized learning (CL) settings, we analyze their performance under Independent and Identically Distributed (IID) and Non-IID data distributions. Results reveal that SGD is the most resilient, achieving the highest accuracy in 87% of cases, while Adam performs best in 13%. Additionally, centralized models outperform FL on CIFAR-10, whereas FL excels on Fashion-MNIST, highlighting the impact of dataset characteristics on adversarial robustness.

Abstract
Medical image captioning is an essential tool to produce descriptive text reports of medical images. One of the central problems of medical image captioning is their poor domain description generation because large pre-trained language models are primarily trained in non-medical text domains with different semantics of medical text. To overcome this limitation, we explore improvements in contrastive learning for X-ray images complemented with soft prompt engineering for medical image captioning and conditional text decoding for caption generation. The main objective is to develop a softprompt model to improve the accuracy and clinical relevance of the automatically generated captions while guaranteeing their complete linguistic accuracy without corrupting the models' performance. Experiments on the MIMIC-CXR and ROCO datasets showed that the inclusion of tailored soft-prompts improved accuracy and efficiency, while ensuring a more cohesive medical context for captions, aiding medical diagnosis and encouraging more accurate reporting.