Abstract
Synthetic datasets are essential for the development and benchmarking of machine learning methods in biomedicine, as they help overcome the pervasive data scarcity in biomedical research. In fields such as immunomics, genomics and proteomics, they enable the development of prediction algorithms, including methods for immune receptor-antigen binding prediction. When generated with transparent and fully specified parameters, synthetic datasets serve as rule-based systems for reproducible and interpretable model testing, an essential step towards digital twins that emulate biological systems for diagnosis and therapy design. A key obstacle, however, is the 'simulation to reality' (sim2real) gap, which describes the uncertainty about whether performance on synthetic data is predictive of performance on experimental data. Divergent statistical and biological properties may erode generalizability and clinical relevance. The lack of standardized sim2real benchmarks impedes validation and widespread adoption. We argue that multilayered validation frameworks, incorporating techniques such as domain adaptation and hybrid validation, and grounded in biological realism, are essential to ensuring that synthetic datasets faithfully capture biological complexity. Closing the sim2real gap will unlock the full translational potential of synthetic data, accelerating diagnostic and therapeutic discovery, guiding clinical decision-making, and advancing the development of predictive digital twins.

Abstract
The stochastic dynamic inventory-routing problem (SDIRP) is a fundamental problem within supply chain operations that integrates inventory management and vehicle routing while handling the stochastic and dynamic nature of exogenous factors unveiled over time, such as customer demands, inventory supply and travel times. While practical applications require dynamic and stochastic decision-making, research in this field has only recently experienced significant growth, with most inventory-routing literature focusing on static variants. This paper reviews the current state of research on SDIRPs, identifying critical gaps and highlighting emerging trends in problem settings and decision policies. We extend the existing inventory-routing taxonomies by incorporating additional problem characteristics to better align models with real-world contexts. As a result, we highlight the need to account for further sources of uncertainty, multiple-supplier networks, perishability, multiple objectives, and pickup and delivery operations. We further categorize each study based on its policy design, investigating how different problem aspects shape decision policies. To conclude, we emphasize that large-scale and real-time problems require more attention and can benefit from decomposition approaches and learning-based methods.

Abstract
Measuring water motion is essential for oceanography, coastal engineering, and marine environmental monitoring. A wide range of sensing technologies is used to quantify water velocity, wave motion, and flow dynamics, each suited to specific spatial and temporal scales. This paper presents a comprehensive review of modern sensor technologies for marine flow measurement, covering mechanical, electromagnetic, pressure-based, acoustic, optical, MEMS-based, inertial, Lagrangian, and remote-sensing approaches. The operating principles, strengths, and limitations of each technology are examined alongside their suitability for different environments and deployment platforms, including moorings, buoys, vessels, autonomous underwater vehicles, and drifters. Special attention is given to rapidly advancing fields such as MEMS flow sensors, multi-sensor fusion, and hybrid systems that combine inertial, acoustic, and optical data. Applications range from high-resolution turbulence measurements to large-scale current mapping and wave characterization. Remaining challenges include biofouling, performance degradation in energetic shallow waters, uncertainties in indirect velocity estimation, and long-term calibration stability. By synthesizing the state of the art across sensing modalities, this review provides a unified perspective on current technological capabilities and identifies key trends shaping the future of marine flow measurement.

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Abstract
The wine production, included in the primary sector is a great cultural and economic deal, both nationally and internationally matters. However, it is highly dependent on natural resources, and traditionally involves high energy and water consumption. Given the global climate change scenario and the need for efficient resource management, it is necessary to implement a sustainable plan for the wine sector to realize sustainable practices. Data from the International Organization of Vine and Wine (OIV), states that global wine production exceeded 260 million hectoliters, in 2022. These has resulted in significant water and energy consumption, with around 500-1200 m(3) of water used per hectare for irrigation and 1.2 gigajoules per hectoliter of wine produced, concluding that more than 80% of total water consumption is associated with irrigation, while more than 90% of energy consumption, is associated with winery processes. In this context, the scarcity of water or the need to achieve carbon neutrality by 2050 makes it essential to adopt energy and water efficiency measures that allow for the sustainable management of resources without endangering the sector's viability. With this in mind, a case study applied to a Portuguese wine industry is presented, including data analysis from water and energy consumption. Also, efficiency metrics will be analyzed, proposing management and decision-support tools based on monitoring and sensor-based techniques. In fact, one example of these efficiency measures deals with the adoption of systems that provide real-time data on consumption patterns and resource availability in order to improve sustainability of the global process production.