Abstract
A configuration of a refractometer sensor is described with the aim of optically detecting the crystallization process of paracetamol. The developed sensing head is based on a conventional cleaved multi-mode fiber. The fiber tip sensor structure was submitted to contact with the liquid of interest (paracetamol fully dissolved in 40% v/v of ethanol/water) and the crystallization process of paracetamol, induced with continued exposure to air, was monitored in real time.

Abstract
Power transformers have an imperative role in the future developments of the electrical grids. Treated as crucial assets for transportation and distribution of electrical energy, transformers are currently being studied regarding to the integration of technologies aiming to diagnose problems and monitoring data of electrical power grid. Furthermore, environmental noise pollution has gained importance, especially in active units of the power grid, located near consumers, such as transformers. Transformers noise can be classified according to its source: core, windings and cooling. This study addresses an experimental characterization of one of the main causes of transformers core noise-magnetostriction of electrical steel. An evaluation of magnetostriction properties of electrical steel, including resistive strain gauges and Fiber Bragg Gratings (FBGs) measurements with an Epstein frame, are presented and discussed. The magnetic flux density influence on hysteretic strain behavior of magnetostriction was evaluated, as well as the effect of a clamping load on core joints. Nowadays, optical interrogators for Bragg gratings have a high acquisition frequencies and wavelength sensitivity when compared to former optical interrogation systems, allowing to evaluate physical phenomena without electromagnetic interference and with equivalent resolution of conventional strain gauges. © 2019 Cassiano C. Linhares et al.

Abstract
Achieving a new generation of enhanced sensors requires the development of structures that result from the fusion of different concepts and effects. In this paper, we combine a special strain sensing structure with an optical sensitivity magnification, through harmonics of the Vernier effect. The recently demonstrated harmonics of the Vernier effect result from increasing the optical path length (OPL) of one of two interferometers by multiple times the OPL of the other interferometer. The effect generates higher magnification factors, proportional to the order of the harmonics. The sensing structure is demonstrated for strain and temperature discrimination, allowing compensation for temperature fluctuations. We explore the complex case of the optical Vernier effect in series, where both interferometers are used as sensing interferometers (no reference interferometer is used). Our results also suggest that the magnification enhancement provided by harmonics of the Vernier effect for a configuration in series is the same as for a configuration in parallel: the magnification factor increases proportionally to the order of the harmonics.

Abstract
The use of sensors in the real world is on the rise, providing information on medical diagnostics for healthcare and improving quality of life. Optical fiber sensors, as a result of their unique properties (small dimensions, capability of multiplexing, chemical inertness, and immunity to electromagnetic fields) have found wide applications, ranging from structural health monitoring to biomedical and point-of-care instrumentation. Furthermore, these sensors usually have good linearity, rapid response for real-time monitoring, and high sensitivity to external perturbations. Optical fiber sensors, thus, present several features that make them extremely attractive for a wide variety of applications, especially biomedical applications. This paper reviews achievements in the area of temperature optical fiber sensors, different configurations of the sensors reported over the last five years, and application of this technology in biomedical applications.

Abstract
In this letter, a strain sensor with high sensitivity enhancement using a special case of Vernier effect is presented. The sensor configuration is composed of two-fiber loop mirrors in a cascaded configuration with opposite strain responses when individually characterized. Thus, the enhanced Vernier effect is explored, which is the most sensitive of three possible cases Vernier effect. Here, the Vernier response depends on the difference between the sensitivities of each Hi-Bi optical fiber. In addition to this, the fundamental and the first harmonic were also explored. The results obtained are a strain sensitivity of (13.3 +/- 0.3) pm/mu epsilon for the carrier, (80.0 +/- 0.3) pm/mu epsilon or the Vernier envelope of the fundamental case and (120 +/- 1) pm/mu epsilon for the Vernier envelope of the first harmonic. The first harmonic could achieve a magnification factor of 8. Considering that the optical interrogation system allows a minimum resolution of 0.02 nm, the minimum measurement step achievable is 0.2 mu epsilon. This work proves the possibility of applying the concept of enhanced Vernier effect to fiber loop mirrors, obtaining higher sensitivity than a standard fiber loop mirror alone. Besides, the sensitivity can be increased through the usage of harmonics of the Vernier effect. Moreover, the use of large interferometers allows a better discretization of the envelope, which implies a greater ease of analysis.

Abstract
Simple Summary Neoplastic diseases are among the leading causes of death worldwide and constitute the main health problem in both human and veterinary medicine, particularly as the occurrence of the disease continues to increase. Comparative oncology is a quickly expanding field that examines both cancer risk and tumor development across species. Characterized by interdisciplinary collaboration, its goal is the improvement of both human and animal health. Canine neoplastic disease occurs spontaneously and has comparable clinical presentation and pathophysiology to corresponding human cancers. Since the nature of the disease is spontaneous, the complex interactions between tumor cells, tissues and the immune system can be better studied. Such relations are otherwise difficult to study in other experimental animal models. Raman spectroscopy has proved to be a suitable technique to detect and study breast microcalcifications. Raman spectroscopy is a specific and sensitive tool for identifying biomarkers of oncologic disease and also shows further potential in differentiating malignant and benign tumors, and these tumors from healthy tissue. Breast cancer is a health problem that affects individual life quality and the family system. It is the most frequent type of cancer in women, but men are also affected. As an integrative approach, comparative oncology offers an opportunity to learn more about natural cancers in different species. Methods based on Raman spectroscopy have shown significant potential in the study of the human breast through the fingerprinting of biological tissue, which provides valuable information that can be used to identify, characterize and discriminate structures in breast tissue, in both healthy and carcinogenic environments. One of the most important applications of Raman spectroscopy in medical diagnosis is the characterization of microcalcifications, which are highly important diagnostic indicators of breast tissue diseases. Raman spectroscopy has been used to analyze the chemical composition of microcalcifications. These occur in benign and malignant lesions in the human breast, and Raman helps to discriminate microcalcifications as type I and type II according to their composition. This paper demonstrates the recent progress in understanding how this vibrational technique can discriminate through the fingerprint regions of lesions in unstained histology sections from canine mammary glands.