Abstract
Capsule endoscopy is becoming the major medical technique for the examination of the gastrointestinal tract, and the detection of small bowel lesions. With the growth of endoscopic capsules and the lack of an appropriate tracking system to allow the localization of lesions, the need to develop software-based techniques for the localisation of the capsule at any given frame is also increasing. With this in mind, and knowing the lack of availability of labelled endoscopic datasets, this work aims to develop a unsupervised method for homography estimation in video capsule endoscopy frames, to later be applied in capsule localisation systems. The pipeline is based on an unsupervised convolutional neural network, with a VGG Net architecture, that estimates the homography between two images. The overall error, using a synthetic dataset, was evaluated through the mean average corner error, which was 34 pixels, showing great promise for the real-life application of this technique, although there is still room for the improvement of its performance. (C) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Peer-review under responsibility of the scientific committee of the CENTERIS -International Conference on ENTERprise Information Systems / ProjMAN - International Conference on Project MANagement / HCist - International Conference on Health and Social Care Information Systems and Technologies.

Abstract
Advances in genomics have driven to the recognition that tumours are populated by different minor subclones of malignant cells that control the way the tumour progresses. However, the spatial and temporal genomic heterogeneity of tumours has been a hurdle in clinical oncology. This is mainly because the standard methodology for genomic analysis is the biopsy, that besides being an invasive technique, it does not capture the entire tumour spatial state in a single exam. Radiographic medical imaging opens new opportunities for genomic analysis by providing full state visualisation of a tumour at a macroscopic level, in a non-invasive way. Having in mind that mutational testing of EGFR and KRAS is a routine in lung cancer treatment, it was studied whether clinical and imaging data are valuable for predicting EGFR and KRAS mutations in a cohort of NSCLC patients. A reliable predictive model was found for EGFR (AUC = 0.96) using both a Multi-layer Perceptron model and a Random Forest model but not for KRAS (AUC = 0.56). A feature importance analysis using Random Forest reported that the presence of emphysema and lung parenchymal features have the highest correlation with EGFR mutation status. This study opens new opportunities for radiogenomics on predicting molecular properties in a more readily available and non-invasive way. © 2019, Springer Nature Switzerland AG.

Abstract
Endoscopic capsules are vitamin-sized devices that leverage from a small wireless camera to create 8 to 10 hour videos of the patients' entire digestive tract, still being the leading tool to diagnose small bowel diseases. The revision of the produced videos is a very time-consuming task, currently conducted manually and frame-by-frame by an expert. Since endoscopic videos usually contain a considerable amount of frames where the mucosa is not clearly visible, the segmentation of the informative regions is a vital component to reduce the necessary time to review each exam. In this work, a CNN encoder-decoder architecture is applied to segment informative regions in small bowel frames of videos of endoscopic capsules. The network was trained and tested with a dataset of 2,929 manually annotated images, achieving a 91.2% Dice coefficient and 83.9% IoU. Furthermore, a video-wise analysis based on the amount of informative pixels in each frame is done.

Abstract
Wireless capsule endoscopy is a relatively novel technique used for imaging of the gastrointestinal tract. Unlike traditional approaches, it allows painless visualisation of the whole of the gastrointestinal tract, including the small bowel, a region of difficult access. Endoscopic capsules record for about 8h, producing around 60,000 images. These are analysed by an expert that identifies abnormalities present in the frames, a process that is very tedious and prone to errors. Thus there is a clear need to develop systems that automatically analyse this data and detect lesions. Lesion detection achieved a precision of 0.94 and a recall of 0.93 by fmetuning the pre-trained DenseNet-161 model. (C) 2019 The Authors. Published by Elsevier B.V.

Abstract
The Sternum is a human bone located in the anterior area of the thoracic cage. It is present in most of the axial cuts provided from the Magnetic Resonance Imaging (MRI) acquisitions. used in the medical field. Detecting the Sternum is relevant as it contains rigid key-points for 3D model reconstructions, assisting in the planning and evaluation of several surgical procedures, and for atlas development by segmenting structures in anatomical proximity. In the absence of applicable approaches for this specific problem. this paper focuses on two distinct automated methods for Sternum segmentation in MRI. The first. relies on K-Means (Clustering) to perform the segmentation, while the second encompasses the closed Minimum Path over the elliptical transformation of Gradient images. A dataset of 14 annotated acquisitions was used for evaluation. The results favored the Gradient approach over Clustering.

Abstract