Abstract
The incidence of colorectal cancer (CRC), one of the deadliest cancers around the world, is increasing. Tissue microenvironment (TME) features such as tumor-infiltrating lymphocytes (TILs) can have a crucial impact on diagnosis or decision-making for treating patients with CRC. While clinical studies showed that TILs improve the host immune response, leading to a better prognosis, inter-observer agreement for quantifying TILs is not perfect. Incorporating machine learning (ML) based applications in clinical routine may promote diagnosis reliability. Recently, ML has shown potential for making progress in routine clinical procedures. We aim to systematically review the TILs analysis based on ML in CRC histological images. Deep learning (DL) and non-DL techniques can aid pathologists in identifying TILs, and automated TILs are associated with patient outcomes. However, a large multi-institutional CRC dataset with a diverse and multi-ethnic population is necessary to generalize ML methods. © 2024 Elsevier Ltd

Abstract

Abstract
Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL) system that learns from weak labels, a sampling strategy that reduces the number of training samples by a factor of six without compromising performance, an approach to leverage a small subset of fully annotated samples, and a prototype with explainable predictions, active learning features and parallelisation. Noting some problems in the literature, this study is conducted with one of the largest WSI colorectal samples dataset with approximately 10,500 WSIs. Of these samples, 900 are testing samples. Furthermore, the robustness of the proposed method is assessed with two additional external datasets (TCGA and PAIP) and a dataset of samples collected directly from the proposed prototype. Our proposed method predicts, for the patch-based tiles, a class based on the severity of the dysplasia and uses that information to classify the whole slide. It is trained with an interpretable mixed-supervision scheme to leverage the domain knowledge introduced by pathologists through spatial annotations. The mixed-supervision scheme allowed for an intelligent sampling strategy effectively evaluated in several different scenarios without compromising the performance. On the internal dataset, the method shows an accuracy of 93.44% and a sensitivity between positive (low-grade and high-grade dysplasia) and non-neoplastic samples of 0.996. On the external test samples varied with TCGA being the most challenging dataset with an overall accuracy of 84.91% and a sensitivity of 0.996.

Abstract

Abstract
Reducing CO(2 )emissions is currently a key policy in most developed countries. In this article, we evaluate whether smart traffic lights can have a relevant role in reducing CO2 emissions in small cities, considering their specific traffic profiles. The research method is a quantitative modelling approach tested by computational simulation. We propose a novel microscopic traffic simulation framework, designed to simulate realistic vehicle kinematics and driver behaviour, and accurately estimate CO(2 )emissions. We also propose and evaluate a routing algorithm for smart traffic lights, specially designed to optimize CO(2 )emissions at intersections. The simulations reveal that deploying smart traffic lights at a single intersection can reduce CO2 emissions by 32% to 40% in the vicinity of the intersection, depending on the traffic density. The simulations show other advantages for drivers: an increase in average speed of 60% to 101% and a reduction in waiting time of 53% to 95%. These findings can be useful for city-level decision makers who wish to adopt smart technologies to improve traffic flows and reduce CO2 emissions. This work also demonstrates that the simulator can play an important role as a tool to study the impact of smart traffic lights and foster the improvement in smart routing algorithms to reduce CO2 emissions.

Abstract
Falls are one of the causes of severe hilliness among elders, and the COVID-19 pandemic increased the number of unattended cases because of the social distancing measures. This study aims to create a dataset that collects the data from a 3-axis acceleration sensor fixed on a hinged board apparatus that mimics a human fall event. The datalogging system uses off-the-shelf devices to measure, collect and store the data. The resulting dataset includes data from different angle positions and heights, corresponding to joints of the lower limbs of the human body (ankle, knee, and hip). We use the dataset with a threshold-based fall detection algorithm. The result from the Receiver Operating Characteristic curve shows a good behavior with a mean Area Under the Curve of 0.77 and allow to compute a best threshold value with False Positive Rate of 14.8% and True Positive rate of 89.1%. The optimal threshold value may vary depending on the specific population, activity patterns, and environmental conditions, which may require further customization and validation in real-world settings. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.