Abstract
We provide a framework for analyzing geographical influence networks that have impacts on visit event sequences for a set of point-of-interests (POIs) in a city. Since mutually-exciting Hawkes processes can naturally model temporal event data and capture interactions between those events, previous work presented a probabilistic model based on Hawkes processes, called CHP model, for finding cooperative structure among online items from their share event sequences. In this paper, based on Hawkes processes, we propose a novel probabilistic model, called RH model, for detecting geographical competitive structure in the set of POIs, and present a method of inferring it from the POI visit event history. We mathematically derive an analytical approximation formula for predicting the popularity of each of the POIs for the RH model, and also extend the CHP model so as to extract geographical cooperative structure. Using synthetic data, we first confirm the effectiveness of the inference method and the validity of the approximation formula. Using real data of Location-Based Social Networks (LBSNs), we demonstrate the significance of the RH model in terms of predicting the future events, and uncover the latent geographical influence networks from the perspective of geographical competitive and cooperative structures. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Abstract
Human mobility patterns are associated with many aspects of our life. With the increase of the popularity and pervasiveness of smartphones and portable devices, the Internet of Things (IoT) is turning into a permanent part of our daily routines. Positioning technologies that serve these devices such as the cellular antenna (GSM networks), global navigation satellite systems (GPS), and more recently the WiFi positioning system (WPS) provide large amounts of spatio-temporal data in a continuous way (data streams). In order to understand human behavior, the detection of important places and the movements between these places is a fundamental task. That said, the proposal of this work is a method for discovering user habits over mobility data without any a priori or external knowledge. Our approach extends a density-based clustering method for spatio-temporal data to identify meaningful places the individuals' visit. On top of that, a Gaussian mixture model (GMM) is employed over movements between the visits to automatically separate the trajectories accordingly to their key identifiers that may help describe a habit. By regrouping trajectories that look alike by day of the week, length, and starting hour, we discover the individual's habits. The evaluation of the proposed method is made over three real-world datasets. One dataset contains high-density GPS data and the others use GSM mobile phone data with 15-min sampling rate and Google Location History data with a variable sampling rate. The results show that the proposed pipeline is suitable for this task as other habits rather than just going from home to work and vice versa were found. This method can be used for understanding person behavior and creating their profiles revealing a panorama of human mobility patterns from raw mobility data.

Abstract
Many aspects of our lives are associated with places and the activities we perform on a daily basis. Most of them are recurrent and demand displacement of the individual between regular places like going to work, school or other important personal locations. To accomplish these recurrent daily activities, people tend to follow regular paths with similar temporal and spatial characteristics, especially because humans are frequently looking for uniformity to support their decisions and make their actions easier or even automatic. In this work, we propose a method for discovering common pathways across users' habits from human mobility data. By using a density-based clustering algorithm, we identify the most preferable locations the users visit, we apply a Gaussian mixture model over these places to automatically separate among all traces, the trajectories that follow patterns in order to discover the representations of individual's habits. By using the longest common sub-sequence algorithm, we search for the trajectories that are more similar over the set of users' habits trips by considering the distance that pairs of users or habits share on the same path. The proposed method is evaluated over two real-world GPS datasets and the results show that the approach is able to detect the most important places in a user's life, detect the routine activities and identify common routes between users that have similar habits paving the way for research techniques in carpooling, recommendation and prediction systems.

Abstract

Abstract
The human gastrointestinal tract harbors approximately 100 trillion microorganisms with different microbial compositions across geographic locations. In this work, we used RNASeq data from stomach samples of non-disease (164 individuals from European ancestry) and gastric cancer patients (137 from Europe and Asia) from public databases. Although these data were intended to characterize the human expression profiles, they allowed for a reliable inference of the microbiome composition, as confirmed from measures such as the genus coverage, richness and evenness. The microbiome diversity (weighted UniFrac distances) in gastric cancer mimics host diversity across the world, with European gastric microbiome profiles clustering together, distinct from Asian ones. Despite the confirmed loss of microbiome diversity from a healthy status to a cancer status, the structured profile was still recognized in the disease condition. In concordance with the parallel host-bacteria population structure, we found 16 human loci (non-synonymous variants) in the European-descendent cohorts that were significantly associated with specific genera abundance. These microbiome quantitative trait loci display heterogeneity between population groups, being mainly linked to the immune system or cellular features that may play a role in enabling microbe colonization and inflammation.

Abstract
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).