Abstract
This work focus on detection of diseases from Heart Rate Variability (HRV) series using Long Short-Term Memory (LSTM) networks. First, non-linear models are used to extract sequences of features that characterize the HRV series. These time sequences are then used as input for the LSTM. HRV recordings from the Noltisalis database are used for training and testing this approach. The results indicate that the procedure provides accuracy scores in the range of 86.7% to 90.0% on the test set.

Abstract
Cardiovascular variability is the result of the activity of several physiological control mechanisms, which involve different variables and operate across multiple time scales encompassing short term dynamics and long range correlations. This study presents a new approach to assess the multiscale complexity of multivariate time series, based on linear parametric models incorporating autoregressive coefficients and fractional integration. The approach extends to the multivariate case recent works introducing a linear parametric representation of multiscale entropy, and is exploited to assess the complexity of cardiovascular and respiratory time series in healthy subjects studied during postural and mental stress.

Abstract
Irregularly spaced time series are commonly encountered in the analysis of time series. A particular case is that in which the collection procedure over time depends also on the observed values. In such situations, there is stochastic dependence between the process being modeled and the times at which the observations are made. Ignoring this dependence can lead to biased estimates and misleading inferences. In this paper, we introduce the concept of preferential sampling in the temporal dimension and we propose a model to make inference and prediction. The methodology is illustrated using artificial data as well a real data set.

Abstract
Time series of (small) counts are common in practice and appear in a wide variety of fields. In the last three decades, several models that explicitly account for the discreteness of the data have been proposed in the literature. However, for multivariate time series of counts several difficulties arise and the literature is not so detailed. This work considers Bivariate INteger-valued Moving Average, BINMA, models based on the binomial thinning operation. The main probabilistic and statistical properties of BINMA models are studied. Two parametric cases are analysed, one with the cross-correlation generated through a Bivariate Poisson innovation process and another with a Bivariate Negative Binomial innovation process. Moreover, parameter estimation is carried out by the Generalized Method of Moments. The performance of the model is illustrated with synthetic data as well as with real datasets.

Abstract
Assessing the dynamical complexity of biological time series represents an important topic with potential applications ranging from the characterization of physiological states and pathological conditions to the calculation of diagnostic parameters. In particular, cardiovascular time series exhibit a variability produced by different physiological control mechanisms coupled with each other, which take into account several variables and operate across multiple time scales that result in the coexistence of short term dynamics and long-range correlations. The most widely employed technique to evaluate the dynamical complexity of a time series at different time scales, the so-called multiscale entropy (MSE), has been proven to be unsuitable in the presence of short multivariate time series to be analyzed at long time scales. This work aims at overcoming these issues via the introduction of a new method for the assessment of the multiscale complexity of multivariate time series. The method first exploits vector autoregressive fractionally integrated (VARFI) models to yield a linear parametric representation of vector stochastic processes characterized by short- and long-range correlations. Then, it provides an analytical formulation, within the theory of state-space models, of how the VARFI parameters change when the processes are observed across multiple time scales, which is finally exploited to derive MSE measures relevant to the overall multivariate process or to one constituent scalar process. The proposed approach is applied on cardiovascular and respiratory time series to assess the complexity of the heart period, systolic arterial pressure and respiration variability measured in a group of healthy subjects during conditions of postural and mental stress. Our results document that the proposed methodology can detect physiologically meaningful multiscale patterns of complexity documented previously, but can also capture significant variations in complexity which cannot be observed using standard methods that do not take into account long-range correlations.

Abstract
uebe.Q is a managing software for solid referential information systems, such as ISO 9000 (for quality) and ISO 1400 (for environment). This is a long-term developed software, encompassing extensive and solid business logic with a long and successful record of deployments. A recent business model change imposed that the evolution and configuration of the software, shifts from the company (and especially the development team) to consultants and other business partners, along with the fact that different systems and respective data/information need to be integrated with minimal intervention of the development team. The so far acceptable rigidity, fragility, immobility and opacity of the software became a problem. Especially, the system was prepared to deal with a specific database respecting a specific schema and code-defined semantics. This paper describes the approach taken to overcome the problems derived form the previous architecture, by adopting (i) ontologies for the specification of business concepts and (ii) an information-integration Decision Support System (DSS) for mapping the domain specific ontologies to the database schemas. © 2020, Springer Nature Switzerland AG.