Abstract

Abstract

Abstract
In this work, a method based on the use of explainable artificial intelligence techniques with multiscale and multidimensional fractal techniques is presented in order to investigate histological images stained with Hematoxylin-Eosin. The CNN GoogLeNet neural activation patterns were explored, obtained from the gradient-weighted class activation mapping and locally-interpretable model-agnostic explanation techniques. The feature vectors were generated with multiscale and multidimensional fractal techniques, specifically fractal dimension, lacunarity and percolation. The features were evaluated by ranking each entry, using the ReliefF algorithm. The discriminative power of each solution was defined via classifiers with different heuristics. The best results were obtained from LIME, with a significant increase in accuracy and AUC rates when compared to those provided by GoogLeNet. The details presented here can contribute to the development of models aimed at the classification of histological images. © 2024 by SCITEPRESS – Science and Technology Publications, Lda.

Abstract

Abstract
Forecasting methods are affected by data quality issues in two ways: 1. they are hard to predict, and 2. they may affect the model negatively when it is updated with new data. The latter issue is usually addressed by pre-processing the data to remove those issues. An alternative approach has recently been proposed, Corrector LSTM (cLSTM), which is a Read & Write Machine Learning (RW-ML) algorithm that changes the data while learning to improve its predictions. Despite promising results being reported, cLSTM is computationally expensive, as it uses a meta-learner to monitor the hidden states of the LSTM. We propose a new RW-ML algorithm, Kernel Corrector LSTM (KcLSTM), that replaces the meta-learner of cLSTM with a simpler method: Kernel Smoothing. We empirically evaluate the forecasting accuracy and the training time of the new algorithm and compare it with cLSTM and LSTM. Results indicate that it is able to decrease the training time while maintaining a competitive forecasting accuracy. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

Abstract
Purpose 2-[F-18]FDG PET/CT plays an important role in the management of pulmonary nodules. Convolutional neural networks (CNNs) automatically learn features from images and have the potential to improve the discrimination between malignant and benign pulmonary nodules. The purpose of this study was to develop and validate a CNN model for classification of pulmonary nodules from 2-[F-18]FDG PET images.Methods One hundred thirteen participants were retrospectively selected. One nodule per participant. The 2-[F-18]FDG PET images were preprocessed and annotated with the reference standard. The deep learning experiment entailed random data splitting in five sets. A test set was held out for evaluation of the final model. Four-fold cross-validation was performed from the remaining sets for training and evaluating a set of candidate models and for selecting the final model. Models of three types of 3D CNNs architectures were trained from random weight initialization (Stacked 3D CNN, VGG-like and Inception-v2-like models) both in original and augmented datasets. Transfer learning, from ImageNet with ResNet-50, was also used.Results The final model (Stacked 3D CNN model) obtained an area under the ROC curve of 0.8385 (95% CI: 0.6455-1.0000) in the test set. The model had a sensibility of 80.00%, a specificity of 69.23% and an accuracy of 73.91%, in the test set, for an optimised decision threshold that assigns a higher cost to false negatives.Conclusion A 3D CNN model was effective at distinguishing benign from malignant pulmonary nodules in 2-[F-18]FDG PET images.