Abstract
Aging involves complex biological processes leading to the decline of living organisms. As population lifespan increases worldwide, the importance of identifying factors underlying healthy aging has become critical. Integration of multi-modal datasets is a powerful approach for the analysis of complex biological systems, with the potential to uncover novel aging biomarkers. In this study, we leveraged publicly available epigenomic, transcriptomic and telomere length data along with histological images from the Genotype-Tissue Expression project to build tissue-specific regression models for age prediction. Using data from two tissues, lung and ovary, we aimed to compare model performance across data modalities, as well as to assess the improvement resulting from integrating multiple data types. Our results demostrate that methylation outperformed the other data modalities, with a mean absolute error of 3.36 and 4.36 in the test sets for lung and ovary, respectively. These models achieved lower error rates when compared with established state-of-the-art tissue-agnostic methylation models, emphasizing the importance of a tissue-specific approach. Additionally, this work has shown how the application of Hierarchical Image Pyramid Transformers for feature extraction significantly enhances age modeling using histological images. Finally, we evaluated the benefits of integrating multiple data modalities into a single model. Combining methylation data with other data modalities only marginally improved performance likely due to the limited number of available samples. Combining gene expression with histological features yielded more accurate age predictions compared with the individual performance of these data types. Given these results, this study shows how machine learning applications can be extended to/in multi-modal aging research. Code used is available at https://github.com/zroger49/multi_modal_age_prediction.

Abstract
APAtizer is a tool designed to analyze alternative polyadenylation events on RNA-sequencing data. The tool handles different file formats, including BAM, htseq, and DaPars bedGraph files. It provides a user-friendly interface that allows users to generate informative visualizations, including Volcano plots, heatmaps, and gene lists. These outputs allow the user to retrieve useful biological insights such as the occurrence of polyadenylation events when comparing two biological conditions. In addition, it can perform differential gene expression, gene ontology analysis, visualization of Venn diagram intersections, and correlation analysis.

Abstract
Identifying participants in narratives is important to understand and extract meaning from unstructured texts. This paper investigates the use of DBpedia and Wikifier for this task. We tested these two knowledge base platforms to evaluate their performance in recognizing and extracting entities in Portuguese-language journalistic narrative texts. The results show that both DBpedia and Wikifier present similar results in identifying participants, around 0.40 in the f1-score. The objective of this paper is to study the potential of knowledge bases to improve the understanding of narratives, in addition to suggesting directions for future research in this domain.

Abstract
The main objective of this study is to contribute to multilingual discourse research by employing ISO-24617 Part 8 (Semantic Relations in Discourse, Core Annotation Schema – DR-core) for annotating discourse relations. Centering around a parallel discourse relations corpus that includes English, Polish, and European Portuguese, we initiate one of the few ISO-based comparative analyses through a multilingual corpus that aligns discourse relations across these languages. In this paper, we discuss the project’s contributions, including the annotated corpus, research findings, and statistics related to the use of discourse relations. The paper further discusses the challenges encountered in complying with the ISO standard, such as defining the scope of arguments and annotating specific relation types like Expansion. Our findings highlight the necessity for clearer definitions of certain discourse relations and more precise guidelines for argument spans, especially concerning the inclusion of connectives. Additionally, the study underscores the importance of ongoing collaborative efforts to broaden the inclusion of languages and more comprehensive datasets, with the objective of widening the reach of ISO-guided multilingual discourse research. © 2024 ELRA Language Resource Association: CC BY-NC 4.0.

Abstract
Recent advances in deep learning have promoted the advent of many computational systems capable of performing intelligent actions that, until then, were restricted to the human intellect. In the particular case of human languages, these advances allowed the introduction of applications like ChatGPT that are capable of generating coherent text without being explicitly programmed to do so. Instead, these models use large volumes of textual data to learn meaningful representations of human languages. Associated with these advances, concerns about copyright and data privacy infringements caused by these applications have emerged. Despite these concerns, the pace at which new natural language processing applications continued to be developed largely outperformed the introduction of new regulations. Today, communication barriers between legal experts and computer scientists motivate many unintentional legal infringements during the development of such applications. In this paper, a multidisciplinary team intends to bridge this communication gap and promote more compliant Portuguese NLP research by presenting a series of everyday NLP use cases, while highlighting the Portuguese legislation that may arise during its development. © 2024 ELRA Language Resource Association.

Abstract
In recent years, there has been a surge in the prevalence of high- and multidimensional temporal data across various scientific disciplines. These datasets are characterized by their vast size and challenging potential for analysis. Such data typically exhibit serial and cross-dependency and possess high dimensionality, thereby introducing additional complexities to conventional time series analysis methods. To address these challenges, a recent and complementary approach has emerged, known as network-based analysis methods for multivariate time series. In univariate settings, quantile graphs have been employed to capture temporal transition properties and reduce data dimensionality by mapping observations to a smaller set of sample quantiles. To confront the increasingly prominent issue of high dimensionality, we propose an extension of quantile graphs into a multivariate variant, which we term Multilayer Quantile Graphs. In this innovative mapping, each time series is transformed into a quantile graph, and inter-layer connections are established to link contemporaneous quantiles of pairwise series. This enables the analysis of dynamic transitions across multiple dimensions. In this study, we demonstrate the effectiveness of this new mapping using synthetic and benchmark multivariate time series datasets. We delve into the resulting network's topological structures, extract network features, and employ these features for original dataset analysis. Furthermore, we compare our results with a recent method from the literature. The resulting multilayer network offers a significant reduction in the dimensionality of the original data while capturing serial and cross-dimensional transitions. This approach facilitates the characterization and analysis of large multivariate time series datasets through network analysis techniques.