Abstract

Abstract
Network human operators' decision-making during grid outages requires significant attention and the ability to perceive real-time feedback from multiple information sources to minimize the number of control actions required to restore service, while maintaining the system and people safety. Data-driven event and alarm management have the potential to reduce human operator cognitive burden. However, the high complexity of events, the data semantics, and the large variety of equipment and technologies are key barriers for the application of Artificial Intelligence (AI) to raw SCADA data. In this context, this paper proposes a methodology to convert a large volume of alarm events into data mining terminology, creating the conditions for the application of modern AI techniques to alarm data. Moreover, this work also proposes two novel data-driven applications based on SCADA data: (i) identification of anomalous behaviors regarding the performance of the protection relays of primary substations, during circuit breaker tripping alarms in High Voltage (HV) and Medium Voltage (MV) lines; (ii) unsupervised learning to cluster similar events in HV line panels, classify new event logs based on the obtained clusters and membership grade with a control parameter that helps to identify rare events. Important aspects associated with data handling and pre-processing are also covered. The results for real data from a Distribution System Operator (DSO) showed: (i) that the proposed method can detect unexpected relay pickup events, e.g., one substation with nearly 41% of the circuit breaker alarms had an 'atypical' event in their context (revealed an overlooked problem on the electrification of a protection relay); (ii) capability to automatically detect and group issues into specific clusters, e.g., SF6 low-pressure alarms and blocks with abnormal profiles caused by event time-delay problems.

Abstract
This paper aims at contributing to personalize anesthetic drug administration during surgery. This study devel-ops an online robust model to predict the maintenance dose of atracurium necessary for the resulting effect, i.e. neuromuscular blockade, to attain a target profile. The model is based on the patient's neuromuscular blockade (NMB) response to the initial bolus only, overcoming the need for information on the patient's weight, age, height and Lean Body Mass usually associated to pharmacokinetic and pharmacodynamic models. To achieve this, a statistical analysis of the response of the patient to the initial bolus is carried out and a set of variables is established as predictors of the maintenance dose. The prediction is accomplished using Classification and Regression Trees, CART, which is a supervised learning method. Simulated data from a stochastic model for the NMB induced by atracurium is used as training set. All the 5000 doses predicted by the model lead to NMB level between 5% and 10%, which supports the proposed predictive model since it is clinically required that the steady state NMB level lies between this two values. The methodology is applied both to simulated and to clinical data sets and is found appropriate for online dose prediction.

Abstract

Abstract
In the last decades propofol became established as an intravenous agent for the induction and maintenance of both sedation and general anesthesia procedures. In order to achieve the desired clinical effects appropriate infusion rate strategies must be designed. Moreover, it is important to avoid or minimize side effects which may be associated with adverse cardiorespiratory effects and delayed recovery. Nowadays, to attain these purposes the continuous propofol delivery is usually performed through target-controlled infusion (TCI) systems whose algorithms rely on pharmacokinetic and pharmacodynamic models (Schraag, 2001). This work presents statistical models to estimate both the infusion rate and the bolus administration. The modeling strategy relies on multivariate linear models for panel data (Wooldridge, 2002), based on patient characteristics such as age, height, weight and gender along with the desired target concentration. A clinical database collected with a RugLoopII device on 84 patients undergoing ultrasonographic endoscopy under sedation-analgesia with propofol and remifentanil, (Gambús et al., 2011), is used to estimate the models (training set with 74 cases) and assess their performance (test set with 10 cases). The results obtained in the test set comprising a broad range of characteristics are satisfactory since the models are able to predict bolus and infusion rates comparable to those of TCI. © 2012 IFAC.

Abstract
The development of automated individualized drug dosage regimens, namely in general anaesthesia environment, has been a subject of interest in the last decades. The use of continuous intravenous drug administration aims at, accurately, maintaining the system at a desired target effect concentration level. Different methods have been proposed for the design of individualized dosage regimens. In this study individual drug dose design is achieved through the characterization of transient initial response induced by a bolus administration of drug. This approach is based on the statistical analysis of the data using Walsh-Fourier spectral analysis which provides information about patient dynamics, allowing the on-line drug dose design using multiple linear least squares and quantile regression technics. The proposed methodology is illustrated in the case where the effect measured on the patient corresponds to the neuromuscular blockade (NMB) level and the drug to the muscle relaxant atracurium.