Abstract
Radon concentration was continuously monitored in a horizontal dead-end gallery near Vyhne (Central Slovakia) from October 2005 to April 2008. Hourly average of radon varied from 2800 to 10 500 Bq/m(3). Temporal variation of radon, which contains periodic and non-periodic signals, spans variation of annual to diurnal scale. Time series of radon were analyzed together with meteorological parameters. The annual variation of radon seems to be connected with the annual variation of atmospheric pressure. The amplitude and shape of diurnal variation of radon changed during the year and is correlated with corresponding changes in the daily amplitude of atmospheric pressure.

Abstract
The ionosphere is a fundamental component of the Earth's atmosphere, impacting human activities such as communication transmissions, navigation systems, satellite functions, power network systems, and natural gas pipelines, even endangering human life or health. As technology moves forward, understanding the impact of the ionosphere on our daily lives becomes increasingly important. CubeSats are a promising way to increase understanding of this important atmospheric layer. This paper reviews the state of the art of CubeSat missions designed for ionospheric studies. Their main instrumentation payload and orbits are also analyzed from the point of view of their importance for the missions. It also focuses on the importance of data and metadata, and makes an approach to the aspects that need to be improved.

Abstract
<p>A novel ionisation detector, previously deployed on meteorological radiosonde flights, has demonstrated responsivity to X-rays and gamma radiation, and additionally, is thought to be sensitive to ionising radiation from cosmic rays. The PiN detector, composed of a 1x1x0.8 cm<sup>3 </sup>CsI(Tl) microscintillator coupled to a PiN photodiode, was deployed on the NRP Sagres sailing vessel on a cruise in the Atlantic between Portugal and the Azores in 2021. The instrument can determine both the count rate and energy of incoming ionising radiation particles.</p><p>The instrument was operational during the voyage in November 2021 when a coronal mass ejection event induced a sudden decrease in the observed cosmic ray intensity, known as a Forbush decrease. We present data recorded by the ionisation detector during this period, to characterise the instrument’s ability to detect cosmic ray events, and we compare the performance with neutron monitoring stations Oulu in Finland, and Dourbes in Belgium. As the PiN detector provides spectral and count rate data, it is possible to group events by their energy, and investigate the count rates of specific energy regimes. This approach is useful as many sources – including high and low energy ionising radiation from cosmic rays – contribute to the background energy spectrum. As a result, more meaningful comparisons and relationships can be established with the neutron monitoring stations.</p>

Abstract
In recent years, the research community has raised serious questions about the replicability and reproducibility of scientific work. In particular, since many studies include some kind of computing work, these are also technological challenges, not only in computer science but in most research domains. Replicability and reproducibility are not easy to achieve, not only because researchers have diverse proficiency in computing technologies, but also because of the variety of computational environments that can be used. Indeed, it is challenging to recreate the same environment using the same frameworks, code, programming languages, dependencies, and so on. In this work, we propose a vision for an Integrated Development Environment allowing the creation, configuration, execution, packaging, and sharing of scientific computational experiments. Such a framework should allow researchers to easily set the code and data used and define the programming languages, code, dependencies, databases, or commands to execute to achieve consistent results for each experiment. With this work, we intend to aid researchers by integrating into the same platform all the stages of the design, execution, and analysis of a computational experiment.

Abstract
Objectives:Angiotensin-converting enzymes' (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these enzymes' activities and BP.Methods:Cross-sectional study of 313 children aged 8-9 years old, included in the birth cohort Generation XXI (Portugal). Anthropometric measurements and 24-h ambulatory BP monitoring were performed. ACE and ACE2 activities were quantified by fluorometric methods.Results:Overweight/obese children demonstrated significantly higher ACE and ACE2 activities, when compared to their normal weight counterparts [median (P25-P75), ACE: 39.48 (30.52-48.97) vs. 42.90 (35.62-47.18) vs. 43.38 (33.49-49.89) mU/ml, P for trend = 0.009; ACE2: 10.41 (7.58-15.47) vs. 21.56 (13.34-29.09) vs. 29.00 (22.91-34.32) pM/min per ml, P for trend < 0.001, in normal weight, overweight and obese children, respectively]. In girls, night-time systolic BP (SBP) and diastolic BP (DBP) increased across tertiles of ACE activity (P < 0.001 and P = 0.002, respectively). ACE2 activity was associated with higher night-time SBP and DBP in overweight/obese girls (P = 0.037 and P = 0.048, respectively) and night-time DBP in the BMI z-score girl adjusted model (P = 0.018). Median ACE2 levels were significantly higher among nondipper girls (16.7 vs. 11.6 pM/min per ml, P = 0.009).Conclusions:Our work shows that obesity is associated with activation of the renin-angiotensin-aldosterone system, with significant increase of ACE and ACE2 activities already in childhood. Also, we report sex differences in the association of ACE and ACE2 activities with BP.

Abstract