Abstract
Breast cancer image fusion consists of registering and visualizing different sets of a patient synchronized torso and radiological images into a 3D model. Breast spatial interpretation and visualization by the treating physician can be augmented with a patient-specific digital breast model that integrates radiological images. But the absence of a ground truth for a good correlation between surface and radiological information has impaired the development of potential clinical applications. A new image acquisition protocol was designed to acquire breast Magnetic Resonance Imaging (MRI) and 3D surface scan data with surface markers on the patient's breasts and torso. A patient-specific digital breast model integrating the real breast torso and the tumor location was created and validated with a MRI/3D surface scan fusion algorithm in 16 breast cancer patients. This protocol was used to quantify breast shape differences between different modalities, and to measure the target registration error of several variants of the MRI/3D scan fusion algorithm. The fusion of single breasts without the biomechanical model of pose transformation had acceptable registration errors and accurate tumor locations. The performance of the fusion algorithm was not affected by breast volume. Further research and virtual clinical interfaces could lead to fast integration of this fusion technology into clinical practice. (C) 2020 The Authors. Published by Elsevier Ltd.

Abstract
The Sternum is a human bone located in the anterior area of the thoracic cage. It is present in most of the axial cuts provided from the Magnetic Resonance Imaging (MRI) acquisitions. used in the medical field. Detecting the Sternum is relevant as it contains rigid key-points for 3D model reconstructions, assisting in the planning and evaluation of several surgical procedures, and for atlas development by segmenting structures in anatomical proximity. In the absence of applicable approaches for this specific problem. this paper focuses on two distinct automated methods for Sternum segmentation in MRI. The first. relies on K-Means (Clustering) to perform the segmentation, while the second encompasses the closed Minimum Path over the elliptical transformation of Gradient images. A dataset of 14 annotated acquisitions was used for evaluation. The results favored the Gradient approach over Clustering.

Abstract
Overuse of antibiotics is causing the environment to become polluted with them. This is a major threat to global health, with bacteria developing resistance to antibiotics because of it. To monitor this threat, multiple antibiotic detection methods have been developed; however, they are normally complex and costly. In this work, an affordable, easy to use alternative based on digital colourimetry is proposed. Photographs of samples next to a colour reference target were acquired to build a dataset. The algorithm proposed detects the reference target, based on binarisation algorithms, in order to standardise the collected images using a colour correction matrix converting from RGB to XYZ, providing a necessary colour constancy between photographs from different devices. Afterwards, the sample is extracted through edge detection and Hough transform algorithms. Finally, the sulfonamide concentration is estimated resorting to an experimentally designed calibration curve, which correlates the concentration and colour information. Best performance was obtained using Hue colour, achieving a relative standard deviation value of less than 3.5%. © 2019, Springer Nature Switzerland AG.

Abstract
Breast Ultrasound has long been used to support diagnostic and exploratory procedures concerning breast cancer, with an interesting success rate, specially when complemented with other radiology information. This usability can further enhance visualization tasks during pre-treatment clinical analysis by coupling the B-Mode images to 3D space, as found in Magnetic Resonance Imaging (MRI) per instance. In fact, Lesions in B-mode are visible and present high detail when comparing with other 3D sequences. This coupling, however, would be largely benefited from the ability to match the various structures present in the B-Mode, apart from the broadly studied lesion. In this work we focus on structures such as skin, subcutaneous fat, mammary gland and thoracic region. We provide a preliminary insight to several structure segmentation approaches in the hopes of obtaining a functional and dependable pipeline for delineating these potential reference regions that will assist in multi-modal radiological data alignment. For this, we experiment with pre-processing stages that include Anisotropic Diffusion guided by Log-Gabor filters (ADLG) and main segmentation steps using K-Means, Meanshift and Watershed. Among the pipeline configurations tested, the best results were found using the ADLG filter that ran for 50 iterations and H-Maxima suppression of 20% and the K-Means method with $$K=6$$. The results present several cases that closely approach the ground truth despite overall having larger average errors. This encourages the experimentation of other approaches that could withstand the innate data variability that makes this task very challenging. © Springer Nature Switzerland AG 2020.

Abstract
Breast cancer imaging research has seen continuous progress throughout the years. Innovative visualization tools and easier planning techniques are being developed. Image segmentation methodologies generally have best results when applied to specific types of exams or sequences, as their features enhance and expedite those approaches. Particular methods have more purchase with the segmentation of particular structures. This is the case with diverse breast structures and the respective lesions on MRI sequences, over T1w and Dyn. The present study presents a methodology to tackle an unapproached task. We aim to facilitate the volumetric alignment of data retrieved from T1w and Dyn sequences, leveraging breast surface segmentation and registration. The proposed method revolves around Canny edge detection and mending potential holes on the surface, in order to accurately reproduce the breast shape. The contour is refined with a Level-set approach and the surfaces are aligned together using a restriction of the Iterative Closest Point (ICP) method. This could easily be applied to other paired same-time, volumetric sequences. The process seems to have promising results as average two-dimensional contour distances are at sub-voxel resolution and visual results seem well within range for the valid transference of other segmented or annotated structures. © Springer Nature Switzerland AG 2020.

Abstract